Cytokine and Chemokine Networks: Pathways to Antiviral Defense

2007 ◽  
pp. 29-46 ◽  
Author(s):  
T. P. Salazar-Mather ◽  
K. L. Hokeness
Keyword(s):  
Antiviral Defense

Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis.

1995 ◽  
Vol 69 (9) ◽  
pp. 5469-5474 ◽  
Author(s):  
D Finke ◽  
U G Brinckmann ◽  
V ter Meulen ◽  
U G Liebert
Keyword(s):  
Measles Virus ◽  
Gamma Interferon ◽  
Antiviral Defense ◽  
Major Mediator

K160 in the RNA‐binding domain of the orf virus virulence factor OV20.0 is critical for its functions in counteracting host antiviral defense

FEBS Letters ◽  
2021 ◽  
Author(s):  
Guan‐Ru Liao ◽  
Yeu‐Yang Tseng ◽  
Ching‐Yu Tseng ◽  
Ying‐Ping Huang ◽  
Ching‐Hsiu Tsai ◽  
...  
Keyword(s):  
Virulence Factor ◽  
Rna Binding ◽  
Binding Domain ◽  
Orf Virus ◽  
Antiviral Defense ◽  
Rna Binding Domain

scholarly journals Recent advances and emerging trends in antiviral defense networking in rice

2021 ◽  
Author(s):  
Lu Wang ◽  
Huiting Xie ◽  
Xiaoyuan Zheng ◽  
Jiasheng Chen ◽  
Shuai Zhang ◽  
...  
Keyword(s):  
Antiviral Defense ◽  
Recent Advances ◽  
Emerging Trends

scholarly journals Simultaneous silencing of two different Arabidopsis genes with a novel virus-induced gene silencing vector

Plant Methods ◽  
2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Kunxin Wu ◽  
Yadan Wu ◽  
Chunwei Zhang ◽  
Yan Fu ◽  
Zhixin Liu ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Double Mutant ◽  
Target Genes ◽  
Rna Binding ◽  
Protein Product ◽  
Antiviral Defense ◽  
Virus Induced Gene Silencing ◽  
Argonaute 2 ◽  
Plant Genes ◽  
Silencing Pathways

Abstract Background Virus-induced gene silencing (VIGS) is a useful tool for functional characterizations of plant genes. However, the penetrance of VIGS varies depending on the genes to be silenced, and has to be evaluated by examining the transcript levels of target genes. Results In this report, we report the development of a novel VIGS vector that permits a preliminary assessment of the silencing penetrance. This new vector is based on an attenuated variant of Turnip crinkle virus (TCV) known as CPB that can be readily used in Arabidopsis thaliana to interrogate genes of this model plant. A CPB derivative, designated CPB1B, was produced by inserting a 46 nucleotide section of the Arabidopsis PHYTOENE DESATURASE (PDS) gene into CPB, in antisense orientation. CPB1B induced robust PDS silencing, causing easily visible photobleaching in systemically infected Arabidopsis leaves. More importantly, CPB1B can accommodate additional inserts, derived from other Arabidopsis genes, causing the silencing of two or more genes simultaneously. With photobleaching as a visual marker, we adopted the CPB1B vector to validate the involvement of DICER-LIKE 4 (DCL4) in antiviral defense against TCV. We further revealed the involvement of ARGONAUTE 2 (AGO2) in PDS silencing and antiviral defense against TCV in dcl2drb4 double mutant plants. These results demonstrated that DOUBLE-STRANDED RNA-BINDING PROTEIN 4 (DRB4), whose protein product (DRB4) commonly partners with DCL4 in the antiviral silencing pathway, was dispensable for PDS silencing induced by CPB1B derivative in dcl2drb4 double mutant plants. Conclusions The CPB1B-based vector developed in this work is a valuable tool with visualizable indicator of the silencing penetrance for interrogating Arabidopsis genes, especially those involved in the RNA silencing pathways.

The splice variant Ntr encoded by the tobacco resistance gene N has a role for negative regulation of antiviral defense responses

2013 ◽  
Vol 84 ◽  
pp. 92-98 ◽  
Author(s):  
Nobumitsu Sasaki ◽  
Masumi Takaoka ◽  
Shobu Sasaki ◽  
Katsuyuki Hirai ◽  
Tetsuo Meshi ◽  
...  
Keyword(s):  
Resistance Gene ◽  
Splice Variant ◽  
Defense Responses ◽  
Negative Regulation ◽  
Antiviral Defense

scholarly journals An Antiviral Defense Role of AGO2 in Plants

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e14639 ◽  
Author(s):  
Jagger J. W. Harvey ◽  
Mathew G. Lewsey ◽  
Kanu Patel ◽  
Jack Westwood ◽  
Susanne Heimstädt ◽  
...  
Keyword(s):  
Antiviral Defense

The Role of Bovine Intraepithelial Leukocyte-Mediated Cytotoxicity in Enteric Antiviral Defense

1992 ◽  
Vol 5 (1) ◽  
pp. 1-13 ◽  
Author(s):  
D.L. GODSON ◽  
M. CAMPOS ◽  
L.A. BABIUK
Keyword(s):  
Antiviral Defense
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