Cartilaginous tissue formation with bone marrow stromal cells by a dynamic compressive stimulation

2007 ◽  
pp. 3291-3294
Author(s):  
Y. Jung ◽  
Soo Hyun Kim ◽  
S. -H. Kim ◽  
Y. H. Kim ◽  
J. Xie ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Tissue Formation ◽  
Cartilaginous Tissue

Mechano-Active Cartilage Tissue Engineering: The Effect of Dynamic Compressive Stimulation

2007 ◽  
Vol 342-343 ◽  
pp. 409-412
Author(s):  
Young Mee Jung ◽  
Soo Hyun Kim ◽  
Sang Heon Kim ◽  
Young Ha Kim ◽  
Jun Xie ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Dynamic Compression ◽  
Cartilage Tissue Engineering ◽  
Marrow Stromal Cells ◽  
Cartilage Tissue ◽  
Cartilaginous Tissue ◽  
Pressing Method ◽  
Biochemical Analyses

Mechano-active scaffolds were fabricated from very elastic poly(lactide-co-carprolactone) by a gel-pressing method. The scaffolds were seeded with bone marrow stromal cells and the continuous compressive deformation was applied to cell-polymer constructs in the chondrogenic media. Then, they were implanted in nude mice subcutaneously to evaluate for the effect of dynamic compression for regeneration of cartilage. From the biochemical analyses, chondrogenic differentiation was sustained and enhanced significantly and chondral extracellular matrix was increased through mechanical stimulation. Histological analyses showed that implants stimulated mechanically formed mature and well-developed cartilaginous tissue, as evidenced by bone marrow derived chondrocytes within lacunae. Consequently, the periodic application of dynamic compression can encourage bone marrow stromal cells to differentiation to chondrogenic lineage and to maintain their phenotypes.

Glucocorticoid exposure reduces expression of sclerostin in bone marrow stromal cells

2013 ◽  
Author(s):  
Sylvia Thiele ◽  
Alexander Rauch ◽  
Jan P Tuckermann ◽  
Lorenz C Hofbauer ◽  
Martina Rauner
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells
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