Vertebrate Eye Development

2000 ◽  
Keyword(s):  
Eye Development ◽  
Vertebrate Eye

Secreted inducers in vertebrate eye development: more functions for old morphogens

2006 ◽  
Vol 16 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Pilar Esteve ◽  
Paola Bovolenta
Keyword(s):  
Eye Development ◽  
Vertebrate Eye

The Xenopus homologue of the Drosophila gene tailless has a function in early eye development

Development ◽  
1998 ◽  
Vol 125 (13) ◽  
pp. 2425-2432 ◽  
Author(s):  
T. Hollemann ◽  
E. Bellefroid ◽  
T. Pieler
Keyword(s):  
Eye Development ◽  
Neural Plate ◽  
Regulatory Function ◽  
Genetic Circuits ◽  
Optic Stalk ◽  
Drosophila Gene ◽  
Ciliary Margin ◽  
Evolutionarily Conserved ◽  
Optic Cup ◽  
Vertebrate Eye

Genetic circuits responsible for the development of photoreceptive organs appear to be evolutionarily conserved. Here, the Xenopus homologue Xtll of the Drosophila gene tailless (tll), which we find to be expressed during early eye development, is characterized with respect to its relationship to vertebrate regulators of eye morphogenesis, such as Pax6 and Rx. Expression of all three genes is first detected in the area corresponding to the eye anlagen within the open neural plate in partially overlapping, but not identical, patterns. During the evagination of the optic vesicle, Xtll expression is most prominent in the optic stalk, as well as in the distal tip of the forming vesicle. In tadpole-stage embryos, Xtll gene transcription is most prominent in the ciliary margin of the optic cup. Inhibition of Xtll function in Xenopus embryos interferes specifically with the evagination of the eye vesicle and, in consequence, Xpax6 gene expression is severely reduced in such manipulated embryos. These findings suggest that Xtll serves an important regulatory function in the earliest phases of vertebrate eye development.

scholarly journals Eye morphogenesis driven by epithelial flow into the optic cup facilitated by modulation of bone morphogenetic protein

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Stephan Heermann ◽  
Lucas Schütz ◽  
Steffen Lemke ◽  
Kerstin Krieglstein ◽  
Joachim Wittbrodt
Keyword(s):  
Marginal Zone ◽  
Eye Development ◽  
Optic Vesicle ◽  
Basal Surface ◽  
Morphogenetic Protein ◽  
Retinal Determination ◽  
Optic Cup ◽  
Morphological Transformations ◽  
Vertebrate Eye ◽  
Ciliary Marginal Zone

The hemispheric, bi-layered optic cup forms from an oval optic vesicle during early vertebrate eye development through major morphological transformations. The overall basal surface, facing the developing lens, is increasing, while, at the same time, the space basally occupied by individual cells is decreasing. This cannot be explained by the classical view of eye development. Using zebrafish (Danio rerio) as a model, we show that the lens-averted epithelium functions as a reservoir that contributes to the growing neuroretina through epithelial flow around the distal rims of the optic cup. We propose that this flow couples morphogenesis and retinal determination. Our 4D data indicate that future stem cells flow from their origin in the lens-averted domain of the optic vesicle to their destination in the ciliary marginal zone. BMP-mediated inhibition of the flow results in ectopic neuroretina in the RPE domain. Ultimately the ventral fissure fails to close resulting in coloboma.

scholarly journals Regulation of vertebrate eye development by Rx genes

2004 ◽  
Vol 48 (8-9) ◽  
pp. 761-770 ◽  
Author(s):  
Travis J. Bailey ◽  
Heithem El-Hodiri ◽  
Li Zhang ◽  
Rina Shah ◽  
Eter H. Mathers ◽  
...  
Keyword(s):  
Eye Development ◽  
Vertebrate Eye

scholarly journals Epigenetic regulatory mechanisms in vertebrate eye development and disease

Heredity ◽  
2010 ◽  
Vol 105 (1) ◽  
pp. 135-151 ◽  
Author(s):  
A Cvekl ◽  
K P Mitton
Keyword(s):  
Eye Development ◽  
Regulatory Mechanisms ◽  
Vertebrate Eye

Expression of FoxE4 and Rx Visualizes the Timing and Dynamics of Critical Processes Taking Place during Initial Stages of Vertebrate Eye Development

2004 ◽  
Vol 26 (5-6) ◽  
pp. 294-307 ◽  
Author(s):  
Carolyn Zilinski ◽  
Isaac Brownell ◽  
Ryuju Hashimoto ◽  
Olga Medina-Martinez ◽  
Eric C. Swindell ◽  
...  
Keyword(s):  
Eye Development ◽  
Vertebrate Eye
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