Adenosine Receptors and Inflammation

2009 ◽  
pp. 215-269 ◽  
Author(s):  
Michael R. Blackburn ◽  
Constance O. Vance ◽  
Eva Morschl ◽  
Constance N. Wilson
Keyword(s):  
Adenosine Receptors

280-LB: Role of A1 and A3 Adenosine Receptors in Whole Body Glucose Metabolism

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 280-LB ◽  
Author(s):  
SHANU JAIN ◽  
DILIP K. TOSH ◽  
MARC REITMAN ◽  
KENNETH A. JACOBSON
Keyword(s):  
Glucose Metabolism ◽  
Adenosine Receptors ◽  
Whole Body

PET Imaging of Adenosine Receptors in Diseases

2019 ◽  
Vol 19 (16) ◽  
pp. 1445-1463 ◽  
Author(s):  
Jindian Li ◽  
Xingfang Hong ◽  
Guoquan Li ◽  
Peter S. Conti ◽  
Xianzhong Zhang ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Adenosine Receptors ◽  
Neurological Diseases ◽  
G Protein Coupled Receptors ◽  
Extracellular Adenosine ◽  
Positron Emission ◽  
Imaging Probes ◽  
Pet Probes ◽  
Cancer And Inflammation ◽  
G Protein Coupled

Adenosine receptors (ARs) are a class of purinergic G-protein-coupled receptors (GPCRs). Extracellular adenosine is a pivotal regulation molecule that adjusts physiological function through the interaction with four ARs: A1R, A2AR, A2BR, and A3R. Alterations of ARs function and expression have been studied in neurological diseases (epilepsy, Alzheimer’s disease, and Parkinson’s disease), cardiovascular diseases, cancer, and inflammation and autoimmune diseases. A series of Positron Emission Tomography (PET) probes for imaging ARs have been developed. The PET imaging probes have provided valuable information for diagnosis and therapy of diseases related to alterations of ARs expression. This review presents a concise overview of various ARs-targeted radioligands for PET imaging in diseases. The most recent advances in PET imaging studies by using ARs-targeted probes are briefly summarized.

Vascular Adenosine Receptors; Potential Clinical Applications

2013 ◽  
Vol 11 (3) ◽  
pp. 327-337 ◽  
Author(s):  
Ming-Fen Ho ◽  
Roselyn B. Rose’Meyer
Keyword(s):  
Adenosine Receptors ◽  
Clinical Applications

Nuclear Factor κB and Adenosine Receptors: Biochemical and Behavioral Profiling

2011 ◽  
Vol 999 (999) ◽  
pp. 1-8 ◽  
Author(s):  
Vickram Ramkumar ◽  
Krishna A. Jhaveri ◽  
Xiaobin Xie ◽  
Sarvesh Jajoo ◽  
Linda A. Toth
Keyword(s):  
Adenosine Receptors ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Behavioral Profiling

New 2-Alkynyl Derivatives of the Acyclic Nucleoside 9-(2,3-Dihydroxypropyl)adenine and Their 6-Guanidinopurine Counterparts as Potential Effectors of Adenosine Receptors

2003 ◽  
Vol 68 (11) ◽  
pp. 2201-2218 ◽  
Author(s):  
Michal Česnek ◽  
Antonín Holý ◽  
Milena Masojídková
Keyword(s):  
Adenosine Receptors ◽  
Sonogashira Coupling ◽  
Acyclic Nucleoside ◽  
Derivatives Of

A series of the new 2-alkynyl derivatives of the acyclic nucleoside 9-(2,3-dihydroxypropyl)- adenine and their 6-guanidinopurine analogues were prepared by the Sonogashira coupling. The effect of the prepared compounds on A1 and A2A receptors was examined.

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