Effects of aortic valve stenosis on coronary artery flow using an in-vitro flow model

Author(s):  
E. Gaillard ◽  
D. Garcia ◽  
L. Kadem ◽  
P. Pibarot ◽  
L. -G. Durand
2021 ◽  
Vol 10 (22) ◽  
pp. 5333
Author(s):  
Philippe Reymond ◽  
Karim Bendjelid ◽  
Raphaël Giraud ◽  
Gérald Richard ◽  
Nicolas Murith ◽  
...  

ECMO is the most frequently used mechanical support for patients suffering from low cardiac output syndrome. Combining IABP with ECMO is believed to increase coronary artery blood flow, decrease high afterload, and restore systemic pulsatile flow conditions. This study evaluates that combined effect on coronary artery flow during various load conditions using an in vitro circuit. In doing so, different clinical scenarios were simulated, such as normal cardiac output and moderate-to-severe heart failure. In the heart failure scenarios, we used peripheral ECMO support to compensate for the lowered cardiac output value and reach a default normal value. The increase in coronary blood flow using the combined IABP-ECMO setup was more noticeable in low heart rate conditions. At baseline, intermediate and severe LV failure levels, adding IABP increased coronary mean flow by 16%, 7.5%, and 3.4% (HR 60 bpm) and by 6%, 4.5%, and 2.5% (HR 100 bpm) respectively. Based on our in vitro study results, combining ECMO and IABP in a heart failure setup further improves coronary blood flow. This effect was more pronounced at a lower heart rate and decreased with heart failure, which might positively impact recovery from cardiac failure.


2002 ◽  
Vol 124 (5) ◽  
pp. 925-932 ◽  
Author(s):  
Peter Kleine ◽  
Mirella Scherer ◽  
Ulf Abdel-Rahman ◽  
Armin A. Klesius ◽  
Hans Ackermann ◽  
...  

1998 ◽  
Vol 28 (10) ◽  
pp. 1691
Author(s):  
Jong-Hoon Koh ◽  
Han-Soo Kim ◽  
Seung-Jea Tahk ◽  
Dong-Jin Kim ◽  
Joon-Han Shin ◽  
...  

1997 ◽  
Vol 19 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Jon Peacock ◽  
Travis Jones ◽  
Christy Tock ◽  
Robert Lutz

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