Reducing Multi-state to Binary Perfect Phylogeny with Applications to Missing, Removable, Inserted, and Deleted Data

Author(s):  
Kristian Stevens ◽  
Dan Gusfield
Keyword(s):  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Charith B. Karunarathna ◽  
Jinko Graham

Abstract Background A perfect phylogeny is a rooted binary tree that recursively partitions sequences. The nested partitions of a perfect phylogeny provide insight into the pattern of ancestry of genetic sequence data. For example, sequences may cluster together in a partition indicating that they arise from a common ancestral haplotype. Results We present an R package to reconstruct the local perfect phylogenies underlying a sample of binary sequences. The package enables users to associate the reconstructed partitions with a user-defined partition. We describe and demonstrate the major functionality of the package. Conclusion The package should be of use to researchers seeking insight into the ancestral structure of their sequence data. The reconstructed partitions have many applications, including the mapping of trait-influencing variants.


2009 ◽  
Vol 9 (4) ◽  
pp. 295-302
Author(s):  
Dan Gusfield ◽  
Yufeng Wu
Keyword(s):  

Author(s):  
Tamar Barzuza ◽  
Jacques S. Beckmann ◽  
Ron Shamir ◽  
Itsik Pe’er
Keyword(s):  

2006 ◽  
Vol 10 (1) ◽  
pp. 97-109 ◽  
Author(s):  
S. Grünewald ◽  
K. T. Huber

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