Role of Epstein-Barr Virus in Burkitt’s Lymphoma

2001 ◽  
pp. 141-151 ◽  
Author(s):  
K. Takada
Keyword(s):  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Oncogenic Role of Epstein-Barr Virus-Encoded RNAs in Burkitt’s Lymphoma Cell Line Akata

1999 ◽  
Vol 73 (12) ◽  
pp. 9827-9831 ◽  
Author(s):  
Jun Komano ◽  
Seiji Maruo ◽  
Koichi Kurozumi ◽  
Takanori Oda ◽  
Kenzo Takada
Keyword(s):  
Cell Line ◽  
Small Rnas ◽  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Soft Agar ◽  
Burkitt's Lymphoma ◽  
Malignant Phenotype ◽  
Barr Virus ◽  
Epstein Barr

ABSTRACT Our previous reports indicated that Epstein-Barr virus (EBV) contributes to the malignant phenotype and resistance to apoptosis in Burkitt’s lymphoma (BL) cell line Akata (N. Shimizu, A. Tanabe-Tochikura, Y. Kuroiwa, and K. Takada, J. Virol. 68:6069–6073, 1994; J. Komano, M. Sugiura, and K. Takada, J. Virol. 72:9150–9156, 1998). Here we report that the EBV-encoded small RNAs (EBERs) are responsible for these phenotypes. Transfection of the EBER genes into EBV-negative Akata clones restored the capacity for growth in soft agar, tumorigenicity in SCID mice, resistance to apoptotic inducers, and upregulated expression of bcl-2 oncoprotein that were originally retained in parental EBV-positive Akata cells and lost in EBV-negative subclones. This is the first report which provides evidence that virus-encoded RNAs (EBERs) have oncogenic functions in BL cells.

scholarly journals Replacement of the Epstein-Barr Virus Plasmid with the EBER Plasmid in Burkitt's Lymphoma Cells

2001 ◽  
Vol 75 (20) ◽  
pp. 9977-9982 ◽  
Author(s):  
Seiji Maruo ◽  
Asuka Nanbo ◽  
Kenzo Takada
Keyword(s):  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma ◽  
Substantial Decrease ◽  
Lymphoma Cells ◽  
Barr Virus ◽  
Epstein Barr ◽  
Do So ◽  
Burkitt’S Lymphoma Cells

ABSTRACT Transfection of an Epstein-Barr virus (EBV)-encoded plasmid containing EBER caused a substantial decrease in the level of plasmid containing EBV in Akata and Mutu Burkitt's lymphoma (BL) lines, but failed to do so in other BL lines. The results suggest that EBER could replace the role of EBV, but other EBV products also play a role in the growth of BL.

scholarly journals Epstein-Barr virus and human diseases: recent advances in diagnosis.

1988 ◽  
Vol 1 (3) ◽  
pp. 300-312 ◽  
Author(s):  
M Okano ◽  
G M Thiele ◽  
J R Davis ◽  
H L Grierson ◽  
D T Purtilo
Keyword(s):  
Epstein Barr Virus ◽  
Recent Decade ◽  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma ◽  
Human Diseases ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Infected Cells ◽  
Epstein Barr

Since the discovery of Epstein-Barr virus (EBV) from a cultured Burkitt's lymphoma cell line in 1964, the virus has been associated with Burkitt's lymphoma, nasopharyngeal carcinoma, and infectious mononucleosis. During the recent decade, EBV has been etiologically implicated in a broad spectrum of human diseases. The precise role of this virus in these diseases is not well understood, but clearly, defective immunosurveillance against the virus may permit an uncontrolled proliferation of EBV-infected cells. As a result, a growing number of cases of EBV-associated B-cell proliferative diseases or lymphoma have been noted in patients with primary and acquired immunodeficiencies. These lymphoproliferative diseases and others, such as chronic mononucleosis syndrome, are leading to new areas of investigation which are providing information regarding the pathogenetic mechanisms of EBV-induced diseases. The early accurate diagnosis of EBV infection can be achieved by performing EBV-specific serology, detecting for EBV-determined nuclear antigen in tissues, establishing spontaneous lymphoid cell lines, and using molecular hybridization techniques for demonstrating the presence of viral genome in affected lesions.

Burkitt's Lymphoma and the Role of Epstein-Barr Virus

1990 ◽  
Vol 36 (3) ◽  
pp. 114-120 ◽  
Author(s):  
J. A. Goldstein ◽  
R. L. Bernstein
Keyword(s):  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals IRAK4 is essential for TLR9-induced suppression of Epstein-Barr virus BZLF1 transcription in Akata Burkitt’s lymphoma cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0186614 ◽  
Author(s):  
Marc Jordi ◽  
Jeannine Marty ◽  
Vanessa Mordasini ◽  
Anna Lünemann ◽  
Scott McComb ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma ◽  
Lymphoma Cells ◽  
Barr Virus ◽  
Epstein Barr ◽  
Burkitt’S Lymphoma Cells

Genome of a mononucleosis epstein-barr virus contains DNA fragments previously regarded to be unique to Burkitt's lymphoma isolates

Cell ◽  
1981 ◽  
Vol 24 (2) ◽  
pp. 543-553 ◽  
Author(s):  
Duncan K. Fischer ◽  
George Miller ◽  
Lyn Gradoville ◽  
Lee Heston ◽  
Marien W. Weststrate ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma ◽  
Dna Fragments ◽  
Barr Virus ◽  
Epstein Barr
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