The Processes Involved in Traumatic Axonal Injury

1997 ◽  
pp. 185-196 ◽  
Author(s):  
T. A. Gennarelli ◽  
D. I. Graham ◽  
L. E. Thibault
Keyword(s):  
Axonal Injury ◽  
Traumatic Axonal Injury

Experimental models of traumatic axonal injury

2010 ◽  
Vol 17 (2) ◽  
pp. 157-162 ◽  
Author(s):  
Hong-Cai Wang ◽  
Yan-Bin Ma
Keyword(s):  
Axonal Injury ◽  
Experimental Models ◽  
Traumatic Axonal Injury

Post-Acute Alterations in the Axonal Cytoskeleton after Traumatic Axonal Injury

2003 ◽  
Vol 20 (2) ◽  
pp. 151-168 ◽  
Author(s):  
William L. Maxwell ◽  
Aisha Domleo ◽  
Gillian McColl ◽  
Saeed S. Jafari ◽  
David I. Graham
Keyword(s):  
Axonal Injury ◽  
Traumatic Axonal Injury ◽  
Axonal Cytoskeleton

Traumatic Axonal Injury after Closed Head Injury in the Neonatal Pig

2002 ◽  
Vol 19 (7) ◽  
pp. 843-853 ◽  
Author(s):  
Ramesh Raghupathi ◽  
Susan S. Margulies
Keyword(s):  
Head Injury ◽  
Axonal Injury ◽  
Closed Head Injury ◽  
Traumatic Axonal Injury ◽  
Closed Head ◽  
Neonatal Pig

Alteration of the neurofilament sidearm and its relation to neurofilament compaction occurring with traumatic axonal injury

1998 ◽  
Vol 784 (1-2) ◽  
pp. 1-6 ◽  
Author(s):  
David O Okonkwo ◽  
Edward H Pettus ◽  
Junta Moroi ◽  
John T Povlishock
Keyword(s):  
Axonal Injury ◽  
Traumatic Axonal Injury

Temporal Profiles of Cytoskeletal Protein Loss following Traumatic Axonal Injury in Mice

2007 ◽  
Vol 32 (12) ◽  
pp. 2006-2014 ◽  
Author(s):  
Gulyeter Serbest ◽  
Matthew F. Burkhardt ◽  
Robert Siman ◽  
Ramesh Raghupathi ◽  
Kathryn E. Saatman
Keyword(s):  
Axonal Injury ◽  
Cytoskeletal Protein ◽  
Traumatic Axonal Injury ◽  
Protein Loss ◽  
Temporal Profiles

scholarly journals Regionally Selective Atrophy After Traumatic Axonal Injury

2010 ◽  
Vol 67 (11) ◽  
Author(s):  
Matthew A. Warner ◽  
Teddy S. Youn ◽  
Tommy Davis ◽  
Alvin Chandra ◽  
Carlos Marquez de la Plata ◽  
...  
Keyword(s):  
Axonal Injury ◽  
Traumatic Axonal Injury

scholarly journals Microglia: A Potential Drug Target for Traumatic Axonal Injury

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Xin Huang ◽  
Wendong You ◽  
Yuanrun Zhu ◽  
Kangli Xu ◽  
Xiaofeng Yang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Drug Target ◽  
Microglial Activation ◽  
Axonal Injury ◽  
Traumatic Axonal Injury ◽  
Potential Drug Target ◽  
Potential Drug ◽  
Microglial Phenotype ◽  
M2 Phenotype

Traumatic axonal injury (TAI) is a major cause of death and disability among patients with severe traumatic brain injury (TBI); however, no effective therapies have been developed to treat this disorder. Neuroinflammation accompanying microglial activation after TBI is likely to be an important factor in TAI. In this review, we summarize the current research in this field, and recent studies suggest that microglial activation plays an important role in TAI development. We discuss several drugs and therapies that may aid TAI recovery by modulating the microglial phenotype following TBI. Based on the findings of recent studies, we conclude that the promotion of active microglia to the M2 phenotype is a potential drug target for the treatment of TAI.

scholarly journals Accuracy in prediction of long-term functional outcome in patients with traumatic axonal injury: a comparison of MRI scales

Brain Injury ◽  
2020 ◽  
Vol 34 (5) ◽  
pp. 595-601 ◽  
Author(s):  
Marleen Maria van Eijck ◽  
Martin Willy Herklots ◽  
Jo Peluso ◽  
Guus Geurt Schoonman ◽  
Annemarie Wilhelma Oldenbeuving ◽  
...  
Keyword(s):  
Functional Outcome ◽  
Axonal Injury ◽  
Traumatic Axonal Injury
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