Attempts at management of idiopathic hypoparathyroidism with vitamin D have led to various reports of resistance to therapy,1 different responses to vitamin D preparations,2 and unexplained toxicity.3 We report a patient with idiopathic hypoparathyroidism who was persistently hypocalcemic during ten months of treatment with vitamin D, 150,000 units/day. After voluntary weight reduction he became hypercalcemic on the same dose of vitamin D. We believe that the toxicity in this instance was due to release of stored vitamin D into the circulation.
CASE REPORT
The patient was referred to the hospital at 12½ years of age because of intracranial calcifications noted on roentgenograms obtained for the evaluation of sinusitis.