Bone Marrow Grafting in Aplastic Anemia After Conditioning with Cyclophosphamide and Total Body Irradiation with Lung Shielding

1980 ◽  
pp. 339-347 ◽  
Author(s):  
E. Gluckman ◽  
A. Devergie ◽  
A. Dutreix ◽  
J. Dutreix ◽  
M. Boiron ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Aplastic Anemia ◽  
Total Body Irradiation ◽  
Total Body ◽  
Bone Marrow Grafting

1128 Total body irradiation (TBI) before bone marrow grafting (BMG): Analysis of late side effects

1995 ◽  
Vol 31 ◽  
pp. S236
Author(s):  
V. Fayrel ◽  
Th. Schmitt ◽  
J.L. Stephan ◽  
D. Guyotat ◽  
G. Puel ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Side Effects ◽  
Total Body Irradiation ◽  
Late Side Effects ◽  
Total Body ◽  
Bone Marrow Grafting ◽  
Late Side

scholarly journals Prevention of graft rejection following bone marrow transplantation

Blood ◽  
1981 ◽  
Vol 57 (1) ◽  
pp. 9-12
Author(s):  
RP Gale ◽  
W Ho ◽  
S Feig ◽  
R Champlin ◽  
A Tesler ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Total Body Irradiation ◽  
Graft Rejection ◽  
Marrow Transplantation ◽  
Low Dose ◽  
Conditioning Regimen ◽  
Actuarial Survival ◽  
Total Body

Bone marrow transplantation from an HLA-identical sibling is increasingly used in the treatment of severe aplastic anemia. One major problem with this approach is graft rejection that occurs in 25%-60% of patients conditioned for transplantation with cyclophosphamide. At most transplant centers it has been difficult to accurately identify patients at high risk for graft rejection. We studied a conditioning regimen of cyclophosphamide (200 mg per kg) and low-dose total body irradiation (3 Gy; equivalent to 300 rad) in 23 consecutive unselected patients with aplastic anemia followed for a minimum of 6 mo. There was only one episode of graft rejection. Graft-versus-host disease and interstitial pneumonitis were not increased by the more intensive conditioning regimen. Actuarial survival was 61% at 1 yr and 49% at 2.5 yr. Cyclophosphamide and low-dose total body irradiation is an effective conditioning regimen in patients with aplastic anemia. It may be particularly useful when accurate predictive tests of graft rejection are not available as is the case in most transplant centers.

Normal Neurodevelopment in Four Young Children Treated With Bone Marrow Transplantation for Acute Leukemia or Aplastic Anemia

PEDIATRICS ◽  
1989 ◽  
Vol 83 (5) ◽  
pp. 753-757
Author(s):  
Thomas A. Kaleita ◽  
W. Donald Shields ◽  
Alan Tesler ◽  
Stephen A. Feig
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Young Children ◽  
Acute Leukemia ◽  
Aplastic Anemia ◽  
Total Body Irradiation ◽  
Marrow Transplantation ◽  
Motor Coordination ◽  
High Dose ◽  
Total Body

Longitudinal neurodevelopmental studies of four consecutive young children treated by bone marrow transplantation for acute leukemia or aplastic anemia are presented. The children, the only four children less than 2 years of age who have received bone marrow transplants for these diseases at UCLA Medical Center, ranged in age from 36 weeks to 24 months at the time of transplantation. Conditioning involved high-dose cyclophosphamide treatment; three also had total body irradiation prior to bone marrow transplantation. Their respective outcomes after follow-up times of 28 months to 71 months posttransplantation are remarkable for normal somatic growth and normal development of intelligence, language, perception, and motor coordination. These findings indicate that future therapeutic studies of infants and young children with acute leukemia or aplastic anemia using total body irradiation, cyclophosphamide, and bone marrow transplantation are not contraindicated by risks of debilitating neurodevelopmental sequelae.

Radiation Damage in Patients Treated by Total-Body Irradiation, Bone Marrow Grafting, and Cyclosporin

1986 ◽  
Vol 105 (3) ◽  
pp. 413 ◽  
Author(s):  
Marion C. Baker ◽  
Sylvia D. Lawler ◽  
Helen Harris ◽  
Ann Barrett ◽  
R. L. Powles
Keyword(s):  
Bone Marrow ◽  
Radiation Damage ◽  
Total Body Irradiation ◽  
Total Body ◽  
Bone Marrow Grafting

Total-Body Irradiation with a High-Dose-Rate Linear Accelerator for Bone-Marrow Transplantation in Aplastic Anemia and Neoplastic Disease

Radiology ◽  
1977 ◽  
Vol 122 (2) ◽  
pp. 523-526 ◽  
Author(s):  
Tae H. Kim ◽  
John Kersey ◽  
Wilfred Sewchand ◽  
Mark E. Nesbit ◽  
William Krivit ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Total Body Irradiation ◽  
Marrow Transplantation ◽  
Linear Accelerator ◽  
High Dose Rate ◽  
High Dose ◽  
Neoplastic Disease ◽  
Total Body

scholarly journals Prevention of graft rejection following bone marrow transplantation

Blood ◽  
1981 ◽  
Vol 57 (1) ◽  
pp. 9-12 ◽  
Author(s):  
RP Gale ◽  
W Ho ◽  
S Feig ◽  
R Champlin ◽  
A Tesler ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Total Body Irradiation ◽  
Graft Rejection ◽  
Marrow Transplantation ◽  
Low Dose ◽  
Conditioning Regimen ◽  
Actuarial Survival ◽  
Total Body

Abstract Bone marrow transplantation from an HLA-identical sibling is increasingly used in the treatment of severe aplastic anemia. One major problem with this approach is graft rejection that occurs in 25%-60% of patients conditioned for transplantation with cyclophosphamide. At most transplant centers it has been difficult to accurately identify patients at high risk for graft rejection. We studied a conditioning regimen of cyclophosphamide (200 mg per kg) and low-dose total body irradiation (3 Gy; equivalent to 300 rad) in 23 consecutive unselected patients with aplastic anemia followed for a minimum of 6 mo. There was only one episode of graft rejection. Graft-versus-host disease and interstitial pneumonitis were not increased by the more intensive conditioning regimen. Actuarial survival was 61% at 1 yr and 49% at 2.5 yr. Cyclophosphamide and low-dose total body irradiation is an effective conditioning regimen in patients with aplastic anemia. It may be particularly useful when accurate predictive tests of graft rejection are not available as is the case in most transplant centers.

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