Mitotic Activity of Satellite Cells in Adult Animals

Author(s):  
Ennio Pannese
Pathology ◽  
1971 ◽  
Vol 3 (3) ◽  
pp. 233-243 ◽  
Author(s):  
D. B. Allbrook ◽  
M. F. Han ◽  
A. E. Hellmuth

1994 ◽  
Vol 76 (1) ◽  
pp. 266-270 ◽  
Author(s):  
E. Schultz ◽  
K. C. Darr ◽  
A. Macius

The proliferative behavior of satellite cells in growing rat soleus and extensor digitorum longus muscles was examined at short periods after initiation of hindlimb unweighting. Mitotic activity of satellite cells in both muscles decreased below weight-bearing control levels within 24 h of initiation of hindlimb unweighting. This satellite cell response was > or = 48 h before any atrophic morphological changes that take place in the muscles. Suppression of mitotic activity was most severe in the soleus muscle where continuous infusion of label demonstrated that virtually all mitotic activity was abolished between 3 and 5 days. The results of this study suggest that satellite cell mitotic activity is a sensitive indicator of primary atrophic changes occurring in growing myofibers and may be a predictor of future morphological changes.


Pathology ◽  
1971 ◽  
Vol 3 (3) ◽  
pp. 233-243 ◽  
Author(s):  
D.B. Allbrook ◽  
M.F. Han ◽  
A.E. Hellmuth

Author(s):  
W.T. Gunning ◽  
G.D. Haselhuhn ◽  
E.R. Phillips ◽  
S.H. Selman

Within the last few years, adrenal cortical tumors with features concordant with the diagnostic criteria attributed to oncocytomas have been reported. To date, only nine reported cases exist in the literature. This report is the tenth case presentation of a presumptively benign neoplasm of the adrenal gland with a rare differentiation. Oncocytomas are well recognized benign tumors of the thyroid, parathyroid, and salivary glands and of the kidney. Other organs also give rise to these types of tumors, however with less frequency than the former sites. The characteristics generally used to classify a tumor as an oncocytoma include the following criteria: the tumor is 1) usually a solitary circumscribed mass with no gross nor microscopic evidence of metastasis (no tissue nor vascular invasion), 2) fairly bland in terms of mitotic activity and nuclear morphology, and 3) composed of large eosinophillic cells in which the cytoplasm is packed full of mitochondria (Figure 1).


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