Human T Lymphocyte Cell Surface Molecules Defined by the Workshop Monoclonal Antibodies (“T Cell Protocol”)

1984 ◽  
pp. 195-212 ◽  
Author(s):  
J. A. Hansen ◽  
P. J. Martin ◽  
P. G. Beatty ◽  
E. A. Clark ◽  
J. A. Ledbetter

Recognition by T lymphocytes of specific antigens in association with self class II antigens leads to expression of the genes coding for the growth and differentiation factor 11-2 and the 11-2 receptor. Studies with monoclonal antibodies have identified at least three T-cell surface molecules which, when stimulated, induce the expression of 11-2 and 11-2 receptor. These are the T-cell antigen receptor (TCR), the CD3 antigen and the CD2 antigen, TCR and CD3 are associated non-covalently on the cell surface. The probable function of CD3 is to act as a signal transducer. There is no compelling evidence in support of CD2 being associated with the TCR-CD 3 complex, but it is evident that the two entities are coupled functionally.


1982 ◽  
Vol 68 (1) ◽  
pp. 135-169 ◽  
Author(s):  
Marion Sarmiento ◽  
Deno P. Dialynas ◽  
David W. Lancki ◽  
Katherine A. Wall ◽  
Marc I. Lorber ◽  
...  

1983 ◽  
Vol 4 (9) ◽  
pp. 256-259 ◽  
Author(s):  
Jeffrey A Bluestone ◽  
Richard J Hodes

Author(s):  
Alan M. Krensky ◽  
Steven J. Mentzer ◽  
Julia L. Greenstein ◽  
Mary Crimmins ◽  
Carol Clayberger ◽  
...  

2002 ◽  
Vol 215 (2) ◽  
pp. 162-172 ◽  
Author(s):  
Jacqueline M McBride ◽  
Thomas Jung ◽  
Jan E de Vries ◽  
Gregorio Aversa

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