Human Cytolytic T-Lymphocyte Clones and Their Function-Associated Cell Surface Molecules

Author(s):  
Alan M. Krensky ◽  
Steven J. Mentzer ◽  
Julia L. Greenstein ◽  
Mary Crimmins ◽  
Carol Clayberger ◽  
...  

Recognition by T lymphocytes of specific antigens in association with self class II antigens leads to expression of the genes coding for the growth and differentiation factor 11-2 and the 11-2 receptor. Studies with monoclonal antibodies have identified at least three T-cell surface molecules which, when stimulated, induce the expression of 11-2 and 11-2 receptor. These are the T-cell antigen receptor (TCR), the CD3 antigen and the CD2 antigen, TCR and CD3 are associated non-covalently on the cell surface. The probable function of CD3 is to act as a signal transducer. There is no compelling evidence in support of CD2 being associated with the TCR-CD 3 complex, but it is evident that the two entities are coupled functionally.


1991 ◽  
Vol 266 (15) ◽  
pp. 9697-9702 ◽  
Author(s):  
A.H. Limper ◽  
B.J. Quade ◽  
R.M. LaChance ◽  
T.M. Birkenmeier ◽  
T.S. Rangwala ◽  
...  

Neuroscience ◽  
1996 ◽  
Vol 73 (1) ◽  
pp. 161-169 ◽  
Author(s):  
G. Gopinath ◽  
V. Sable ◽  
K. Sailaja ◽  
P.N. Tandon

2011 ◽  
Vol 134 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Laia Llinàs ◽  
Adriana Lázaro ◽  
Jose de Salort ◽  
Jessica Matesanz-Isabel ◽  
Jordi Sintes ◽  
...  

Author(s):  
D. N. J. Hart ◽  
G. J. Clark ◽  
J. W. Dekker ◽  
D. B. Fearnley ◽  
M. Kato ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document