Results of the Treatment of Open Fractures, Aspects of Antibiotic Therapy

Author(s):  
M. Rojczyk
Author(s):  
Farzad Amouzadeh Omrani ◽  
Mohsen Elahi ◽  
Mohammad Mahdi Sarzaeem ◽  
Shahram Sayadi ◽  
Hamed Farzaneh

Background: Intramedullary nailing (IM nailing) is the standard of care for the treatment of most diaphyseal lower extremity fractures. A few studies have assessed and compared the infection rate following reamed and unreamed IM nailing in open long bone fractures. In the present study, we attempted to compare the infection rate between two procedures in open fractures of tibia. Methods: In this prospective study, we included consecutive patients suffering from open fractures of tibia (Gustilo subtypes II or IIIA) who required IM nailing. Patients younger than 16 years old, other Gustilo types (I, IIIB, and IIIC), fractures reaching to the tibial plateau articular surface, and simultaneous fractures of other bones in the extremity were excluded. All patients were followed up for one year to assess the postoperative infection rate. Results: Of 59 patients, 37 underwent reamed IM nailing and 22 underwent unreamed IM nailing. In reamed group, 4 cases (10.8%) experienced an infection requiring reoperation and antibiotic therapy, while in the unreamed group, it was 5 cases (22.7%). The difference between the groups was not statistically significant. Conclusion: Reamed and unreamed IM nailing procedures for fractures of tibia have similar outcome regarding long-term postoperative infections that require reoperation and antibiotic therapy.


1987 ◽  
Vol 12 (1) ◽  
pp. 123-124
Author(s):  
J. P. SLOAN ◽  
A. F. DOVE ◽  
M. MAHESON ◽  
A. N. COPE ◽  
K. R. WELSH.

A prospective trial was undertaken on 85 adult patients with open fractures of the distal phalanges of less than 6 hours duration, treated by conventional surgery. They either received no antibiotic therapy, or cephradine in short or long courses. The infection rate was 30% in the group without antibiotics and less than 3% in the treated groups. Three different antibiotics regimes were compared, with no difference in the infection rate: therefore the simplest and surest method, a single pre-operative dose and a single post-operative dose, is recommended.


2003 ◽  
Vol 10 (3) ◽  
pp. 79-84
Author(s):  
S V Sergeev ◽  
S Ezmekna ◽  
L I Zelenshna ◽  
E A Novozhilova ◽  
V L Golubeva ◽  
...  

The results of prevention and treatment of purulent and septic complications are presented. There were 21 patients with closed and open fractures and 21 patients with post-traumatic purulent complications and trauma sequelae. Thirteen patients had multiple and concomitant injuries. Treatment included the combination of surgical and conservative methods of fracture stabilization, antibiotic therapy as well as detoxication by efferent methods and immunocorrection.


Author(s):  
Terrence Endres ◽  
Kristopher Danielson ◽  
Stephen O'Neil ◽  
Shawn Brandenburg ◽  
Teresa Hall ◽  
...  

2019 ◽  
Vol 55 (3) ◽  
pp. 193-198
Author(s):  
Hannah C. Johnson ◽  
Abby M. Bailey ◽  
Regan A. Baum ◽  
Stephanie B. Justice ◽  
Kyle A. Weant

Purpose: Prophylactic antibiotic therapy is a standard of care for patients who present with open fractures due to the risk of infectious complications. This study was conducted to characterize the use of initial prophylactic antibiotic use in open fractures, guideline compliance, and its impact on care. Methods: Retrospective chart review of adult patients presenting with an open fracture to a Level 1 Trauma Center Emergency Department over a 12-month period was conducted. Results: Of the 202 patients meeting inclusion criteria, overall compliance with guideline recommendations for antibiotic prophylaxis was found to be 33.2%. The duration of prophylactic therapy was significantly longer in the noncompliant group and among those who received a secondary antibiotic ( P < .05 for both comparisons). The duration of therapy was found to be significantly longer in those patients who developed an infection ( P < .001). Those who developed an infection had a longer hospital length of stay (LOS) ( P < .001) and intensive care unit LOS ( P = .002). In addition, those who developed an infection had significantly more surgeries ( P < .001) and received more red blood cell transfusions ( P < .001). Correlation analysis confirmed a significant association between infection and duration of antibiotic prophylaxis ( P = .02), number of surgeries ( P < .0001), and number of transfusions ( P < .0001). Conclusion: Guideline compliance was exceedingly low due to the extended duration of initial antibiotic therapy and did not appear to yield any clinical benefits. Infection was significantly associated with longer duration of initial prophylactic therapy and morbidity. Opportunities exist to elevate compliance with guidelines and to reevaluate prophylactic antimicrobial therapy in this setting.


Injury ◽  
2012 ◽  
Vol 43 ◽  
pp. S29
Author(s):  
M. Giesecke ◽  
C. Kleber ◽  
C.A. Becker ◽  
R.A. Schiller ◽  
N.P. Haas ◽  
...  

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