Influence of Pyrazolones on Hepatic Glutathione in Rats

1985 ◽  
pp. 366-369 ◽  
Author(s):  
E. Bien ◽  
M. Witt
Keyword(s):  
Hepatic Glutathione

Bergenin Exhibits Hepatoprotective Activity Against Ethanol-Induced Oxidative Stress in ICR Mice

2019 ◽  
Vol 18 (4) ◽  
pp. 297-302
Author(s):  
Sriset Yollada ◽  
Chatuphonprasert Waranya ◽  
Jarukamjorn Kanokwan
Keyword(s):  
Reactive Oxygen Species ◽  
Gallic Acid ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Hepatic Injury ◽  
Reduced Glutathione ◽  
Reactive Oxygen ◽  
Hepatoprotective Activity ◽  
Oxygen Species ◽  
Hepatic Glutathione

Bergenin is a C-glucoside derivative of gallic acid but its antioxidant and hepatoprotective effects have not previously been compared with gallic acid. Male ICR mice were administered bergenin (10, 50, and 250 mg/kg/day) or gallic acid (100 mg/kg/day) for 7 consecutive days before a single administration of ethanol (5 g/kg). Liver sections were histopathologically examined. Aspartate aminotransferase, alanine aminotransferase, reactive oxygen species, and malondialdehyde levels were determined in plasma. Total glutathione, reduced glutathione, and oxidized glutathione levels were determined in liver homogenates. Ethanol induced hepatic injury with prominent histopathological markers including nuclear pyknosis and necrotic areas and this accorded with increases in the plasma levels of aspartate aminotransferase, alanine aminotransferase, reactive oxygen species, and malondialdehyde. Moreover, ethanol disturbed hepatic glutathione homeostasis by reducing glutathione stores. Hepatic injury in the ethanol-induced mice was prevented with bergenin and gallic acid by significant decreases in plasma aspartate aminotransferase, alanine aminotransferase, reactive oxygen species, and malondialdehyde levels and restoration of the hepatic glutathione profile through an increase in the reduced glutathione/oxidized glutathione ratio. Bergenin at 10 mg/kg/day showed comparable hepatoprotective activity to gallic acid in an ethanol-induced mouse model of oxidative stress. Therefore, bergenin might be a promising candidate for further development as a novel hepatoprotective product.

scholarly journals Hepatic Glutathione Reductase

1962 ◽  
Vol 237 (5) ◽  
pp. 1589-1595 ◽  
Author(s):  
Charles E. Mize ◽  
Robert G. Langdon
Keyword(s):  
Glutathione Reductase ◽  
Hepatic Glutathione

Hepatic glutathione suppression by the α-adrenoreceptor stimulating agents phenylephrine and clonidine

Toxicology ◽  
1991 ◽  
Vol 69 (3) ◽  
pp. 279-290 ◽  
Author(s):  
Raymond D. Harbison ◽  
Robert C. James ◽  
Stephen M. Roberts
Keyword(s):  
Hepatic Glutathione

Effect of purified rat and hamster hepatic glutathione S-transferases on the microsome mediated binding of aflatoxin B1 to DNA

1986 ◽  
Vol 33 (1) ◽  
pp. 1-9 ◽  
Author(s):  
H.G. Raj ◽  
H.R. Prasanna ◽  
P.N. Magee ◽  
P.D. Lotlikar
Keyword(s):  
Aflatoxin B1 ◽  
Hepatic Glutathione ◽  
Glutathione S Transferases

scholarly journals In vivo monitoring of hepatic glutathione in anesthetized rats by13C NMR

2002 ◽  
Vol 48 (3) ◽  
pp. 430-439 ◽  
Author(s):  
Jeffrey M. Macdonald ◽  
Olga Schmidlin ◽  
Thomas L. James
Keyword(s):  
In Vivo Monitoring ◽  
Anesthetized Rats ◽  
Hepatic Glutathione

Toxic Doses of Acetaminophen Suppress Hepatic Glutathione Synthesis in Rats

Hepatology ◽  
2007 ◽  
Vol 2 (1) ◽  
pp. 8S-12S ◽  
Author(s):  
Bernhard H. Lauterburg ◽  
Jerry R. Mitchell
Keyword(s):  
Glutathione Synthesis ◽  
Hepatic Glutathione
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