A Controlled Trial of CPD-Choline Administration in Premature Infants with Respiratory Distress Syndrome

1988 ◽  
pp. 362-368
Author(s):  
A. Valls-Soler ◽  
P. Sanjurjo ◽  
I. Lopez de Heredia
Author(s):  
Melissa H. Spiel ◽  
John Zupancic

Two hundred eighty-two patients at risk for premature delivery were included in this controlled trial of betamethasone therapy versus placebo. Of those included, 213 were in spontaneous premature labor. Ethanol or salbutamol infusions were used to delay delivery while steroid or placebo was given. Among those infants born to mothers who received betamethasone, there were no deaths with hyaline membrane disease or intraventricular hemorrhage. Respiratory distress syndrome occurred less often in those who received betamethasone than in controls (9% vs. 25.8%, p = 0.003), but this difference was primarily for those neonates born less than 32 weeks gestation who had been treated for at least 24 hours before delivery. This article reviews this hallmark study and provides contemporary context for its findings.


1981 ◽  
Vol 15 ◽  
pp. 667-667
Author(s):  
Alan H Klein ◽  
Barbara Foley ◽  
Thomas P Foley ◽  
Hugh H Macdonald ◽  
Delbert A Fisher

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