Longevity of Rainbow Trout Antibody-Producing Cells after in Vitro Immunization Culture

1988 ◽  
pp. 228-231
Author(s):  
O. W. Dixon ◽  
D. P. Anderson ◽  
R. Kimenai ◽  
E. F. Lizzio
Keyword(s):  
Rainbow Trout ◽  
In Vitro Immunization

The in vitro effect of kynurenic acid on the rainbow trout (Oncorhynchus mykiss) leukocyte and splenocyte activity

2014 ◽  
Vol 17 (3) ◽  
pp. 453-458 ◽  
Author(s):  
J. Małaczewska ◽  
A. K. Siwicki ◽  
R. Wójcik ◽  
W. a. Turski ◽  
E. Kaczorek
Keyword(s):  
Rainbow Trout ◽  
Immune Cells ◽  
Kynurenic Acid ◽  
Kynurenine Pathway ◽  
Phagocytic Cells ◽  
Mitogenic Response ◽  
Tryptophan Degradation ◽  
Selective Ligand ◽  
Vitro Effect

Abstract Kynurenic acid (KYNA), an endogenous neuroprotectant formed along the kynurenine pathway of tryptophan degradation, is a selective ligand of the GPR35 receptor, which can be found on the surface of various populations of human immune cells. In infections and inflammations, KYNA produces an anti-inflammatory effect through this receptor, by depressing the synthesis of reactive oxygen species and pro-inflammatory cytokines. However, it is still unrecognized whether receptors for kynurenic acid are also localized on immune cells of poikilothermic animals, or whether KYNA is able to affect these cells. The objective of this study has been to determine the effect of different concentrations of kynurenic acid (12.5 μM to 10 mM) on the viability and mitogenic response of lymphocytes and on the activity of phagocytic cells isolated from blood and the spleen of rainbow trout. The results imply low toxicity of kynurenic acid towards fish immune cells, and the proliferative effect observed at the two lowest concentrations of KYNA (12.5 μM and 25 μM) seems indicative of endogenous kynurenic acid being capable of activating fish lymphocytes. Non-toxic, micromole concentrations of KYNA, however, had no influence on the mitogenic response of lymphocytes nor on the activity of phagocytes in rainbow trout under in vitro conditions. There is some likelihood that such an effect could be observed at lower, nanomole concentrations of KYNA.

The production of human monoclonal anti-MMTV antibodies by in vitro immunization with anti-idiotypic antibodies

1991 ◽  
Vol 28 (1) ◽  
pp. 65-71 ◽  
Author(s):  
M. Blank ◽  
I.N. Smorodinsky ◽  
I. Keydar ◽  
S. Chaitchik ◽  
Y. Shoenfeld
Keyword(s):  
In Vitro Immunization

In Vivo and In Vitro Debromination of Decabromodiphenyl Ether (BDE 209) by Juvenile Rainbow Trout and Common Carp

2006 ◽  
Vol 40 (15) ◽  
pp. 4653-4658 ◽  
Author(s):  
Heather M. Stapleton ◽  
Brian Brazil ◽  
R. David Holbrook ◽  
Carys L. Mitchelmore ◽  
Rae Benedict ◽  
...  
Keyword(s):  
Rainbow Trout ◽  
Common Carp ◽  
Decabromodiphenyl Ether ◽  
Juvenile Rainbow Trout ◽  
Bde 209

scholarly journals Estrogen-Like Activity of Perfluoroalkyl Acids In Vivo and Interaction with Human and Rainbow Trout Estrogen Receptors In Vitro

2010 ◽  
Vol 120 (1) ◽  
pp. 42-58 ◽  
Author(s):  
Abby D. Benninghoff ◽  
William H. Bisson ◽  
Daniel C. Koch ◽  
David J. Ehresman ◽  
Siva K. Kolluri ◽  
...  
Keyword(s):  
Rainbow Trout ◽  
Estrogen Receptors ◽  
Perfluoroalkyl Acids

scholarly journals In vitro subacute cataractogenic study in rainbow trout lens.

1987 ◽  
Vol 10 (9) ◽  
pp. 443-448 ◽  
Author(s):  
MITSUSHI HIKIDA ◽  
SHUZO IWATA
Keyword(s):  
Rainbow Trout

Estrogenic activity of multicyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss) in vitro assays

2019 ◽  
Vol 207 ◽  
pp. 43-51 ◽  
Author(s):  
Richard C. Kolanczyk ◽  
Jeffrey S. Denny ◽  
Barbara R. Sheedy ◽  
Patricia K. Schmieder ◽  
Mark A. Tapper
Keyword(s):  
Rainbow Trout ◽  
Oncorhynchus Mykiss ◽  
Aromatic Hydrocarbons ◽  
Estrogenic Activity ◽  
In Vitro Assays ◽  
Rainbow Trout Oncorhynchus Mykiss
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