Effects of Tumor Necrosis Factor on the Hypothalamic-Pituitary-Adrenal Axis

1993 ◽  
pp. 681-686
Author(s):  
K. Mealy ◽  
B. G. Robinson ◽  
J. A. Majzoub ◽  
D. W. Wilmore
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Necrosis Factor

Plasma Interleukin-1, Tumour Necrosis Factor and Hypothalamic-Pituitary-Adrenal Axis Responses During Migraine Attacks

Cephalalgia ◽  
1991 ◽  
Vol 11 (2) ◽  
pp. 65-67 ◽  
Author(s):  
JJ van Hilten ◽  
MD Ferrari ◽  
JWM Van der Meer ◽  
HJ Gijsman ◽  
BJ Looij
Keyword(s):  
Body Temperature ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Adrenocorticotropic Hormone ◽  
Interleukin 1 ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Necrosis Factor

To evaluate systemic cytokine and hypothalamic-pituitary-adrenal axis responses in migraine, we measured plasma levels of tumour necrosis factor, interleukin-1, adrenocorticotropic hormone, and cortisol, as well as body temperature during and between attacks in 20 migraine patients. We found no evidence of systemic rise of cytokines during migraine attacks. Plasma cortisol and adrenocorticotropic hormone responses were similar to those found to experimentally-induced pain in normal subjects, i.e. elevated cortisol and unchanged adrenocorticotropic hormone levels. Unexpectedly, body temperature tended to be lower during attacks.

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