Positron Emission Tomography: Evaluation of Myocardial Blood Flow and Viability Before and Following Coronary Revascularization

1994 ◽  
pp. 113-132
Author(s):  
S. G. Sawada ◽  
M. Schwaiger
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Coronary Revascularization ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Improved regional myocardial blood flow and flow reserve after coronary revascularization as assessed by serial 15O-water positron emission tomography/computed tomography

2019 ◽  
Vol 21 (1) ◽  
pp. 36-46 ◽  
Author(s):  
Tadao Aikawa ◽  
Masanao Naya ◽  
Kazuhiro Koyanagawa ◽  
Osamu Manabe ◽  
Masahiko Obara ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Coronary Revascularization ◽  
Emission Tomography ◽  
Regional Stress ◽  
Flow Reserve ◽  
Positron Emission ◽  
Stable Cad

Abstract Aims Myocardial perfusion imaging without and with quantitative myocardial blood flow (MBF) and myocardial flow reserve (MFR) plays an important role in the diagnosis and risk stratification of patients with stable coronary artery disease (CAD). We aimed to quantify the effects of coronary revascularization on regional stress MBF and MFR and to determine whether the presence of subendocardial infarction was associated with these changes. Methods and results Forty-seven patients with stable CAD were prospectively enrolled. They underwent 15O-water positron emission tomography at baseline and 6 months after optimal medical therapy alone (n = 16), percutaneous coronary intervention (PCI) (n = 18), or coronary artery bypass grafting (CABG) (n = 13). Stenosis of ≥50% diameter was detected in 98/141 vessels (70%). The regional MFR was significantly increased from baseline to follow-up [1.84 (interquartile range, IQR 1.28–2.17) vs. 2.12 (IQR 1.69–2.63), P < 0.001] in vessel territories following PCI or CABG due to an increase in the stress MBF [1.33 (IQR 0.97–1.67) mL/g/min vs. 1.64 (IQR 1.38–2.17) mL/g/min, P < 0.001], whereas there was no significant change in the regional stress MBF or MFR in vessel territories without revascularization. A multilevel mixed-effects models adjusted for baseline characteristics, subendocardial infarction assessed by cardiovascular magnetic resonance imaging, and intra-patient correlation showed that the degree of angiographic improvement after coronary revascularization was significantly associated with increased regional stress MBF and MFR (P < 0.05 for all). Conclusion Coronary revascularization improved the regional stress MBF and MFR in patients with stable CAD. The magnitude of these changes was associated with the extent of revascularization independent of subendocardial infarction.

scholarly journals Measurement of heritability of myocardial blood flow by positron emission tomography: the Twins Heart Study

Heart ◽  
2012 ◽  
Vol 98 (6) ◽  
pp. 495-499 ◽  
Author(s):  
Shaoyong Su ◽  
John Votaw ◽  
Tracy Faber ◽  
Durreshahwar Khan ◽  
J Douglas Bremner ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Emission Tomography ◽  
Positron Emission ◽  
Heart Study

scholarly journals Assessment of Myocardial Blood Flow and Cardiac FDG Uptake Using Positron Emission Tomography

2017 ◽  
Vol 3 (1) ◽  
pp. 205-209 ◽  
Author(s):  
Osamu Manabe ◽  
Masanao Naya ◽  
Keiichiro Yoshinaga ◽  
Noriko Oyama-Manabe ◽  
Hiroshi Ohira ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Emission Tomography ◽  
Fdg Uptake ◽  
Positron Emission

P250 Evaluation of coronary endothelial dysfunction by positron emission tomography: does gender make a difference

2020 ◽  
Vol 41 (Supplement_1) ◽  
Author(s):  
A Aljizeeri ◽  
M Alali Alfaris ◽  
D Ahmed ◽  
J Farea ◽  
A Elneama ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Endothelial Dysfunction ◽  
Myocardial Blood Flow ◽  
Left Ventricular ◽  
Hazard Ratio ◽  
Emission Tomography ◽  
Left Ventricular Ejection ◽  
Positron Emission ◽  
High Calcium

Abstract Funding Acknowledgements None Introduction Endothelial dysfunction (ED) manifested as abnormality of coronary microvasculature is associated with poor prognosis in patients presenting with chest pain. ED can be noninvasively evaluated by assessment of coronary flow reserve with positron emission tomography (PET). Studies directly comparing ED in men and women are limited. The aim of this study is to compare gender differences in ED as measured by CFR on PET myocardial perfusion imaging. Methods All the consecutive patients referred to PET-MPI between May 2011 and June 2018 were reviewed. Patient without known CAD who had normal perfusion were included in the analysis. Patient with abnormal electrocardiogram, significant transient ischemic dilatation, low left ventricular ejection fraction and high calcium score (>1000 AU) and renal failure were excluded. CFR is calculated as the ratio of stress/rest myocardial blood flow. CFR < 2 was considered as abnormal indicating the presence of ED. Results 1711 patients were included in the analysis (mean age 60.2 ± 10 year, 68% females). Females were older and had higher BMI and diabetes (DM). Both resting and peak myocardial blood flow (MBF) was higher in females (1.16 vs 1.02 (p < 0.0001)) and 3.26 vs 2.9 (p < 0.001)0 respectively.  Around 68% of males had abnormal CFR (<2) compared to 63% of females (p = 0.05). After adjusting for the confounders, female gender was associated with higher peak MBF (Hazard ratio 0.29, 95% CI 0.19 –0.40, p < 0.001) and lower chance of having ED (Hazard ratio -0.15, 95% CI -0.29 - -0.005, p = 0.049) Conclusions Endothelial dysfunction as measured noninvasively by CFR on PET is prevalent among both sexes. Higher level of peak MBF in females may call for a different cut-off for abnormal CFR in women. Outcome studies are required to evaluate the clinical utility and prognostic value of such a cut-off.

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