Membranes, Dichroism and Receptor Sensitivity

1975 ◽  
pp. 237-259 ◽  
Author(s):  
Simon B. Laughlin ◽  
Randolf Menzel ◽  
Allan W. Snyder
Keyword(s):  
Receptor Sensitivity

scholarly journals Intracellular recordings from gecko photoreceptors during light and dark adaptation.

1975 ◽  
Vol 66 (5) ◽  
pp. 617-648 ◽  
Author(s):  
J Kleinschmidt ◽  
J E Dowling
Keyword(s):  
Membrane Potential ◽  
Dark Adaptation ◽  
Horizontal Cell ◽  
Intracellular Recordings ◽  
Receptor Sensitivity ◽  
Intensity Curve ◽  
Voltage Range ◽  
Voltage Change ◽  
Sensitivity Change ◽  
Compression Treatment

Intracellular recordings were obtained from rods in the Gekko gekko retina and the adaptation characteristics of their responses studied during light and dark adaptation. Steady background illumination induced graded and sustained hyperpolarizing potentials and compressed the incremental voltage range of the receptor. Steady backgrounds also shifted the receptor's voltage-intensity curve along the intensity axis, and bright backgrounds lowered the saturation potential of the receptor. Increment thresholds of single receptors followed Weber's law over a range of about 3.5 log units and then saturated. Most of the receptor sensitivity change in light derived from the shift of the voltage-intensity curve, only little from the voltage compression. Treatment of the eyecup with sodium aspartate at concentrations sufficient to eliminate the beta-wave of the electroretinogram (ERG) abolished initial transients in the receptor response, possibly indicating the removal of horizontal cell feedback. Aspartate treatment, however, did not significantly alter the adaptation characteristics of receptor responses, indicating that they derive from processes intrinsic to the receptors. Dark adaptation after a strongly adapting stimulus was similarly associated with temporary elevation of membrane potential, initial lowering of the saturation potential, and shift of the voltage-intensity curve. Under all conditions of adaptation studied, small amplitude responses were linear with light intensity. Further, there was no unique relation between sensitivity and membrane potential suggesting that receptor sensitivity is controlled at least in part by a step of visual transduction preceding the generation of membrane voltage change.

scholarly journals Receptor sensitivity in bacterial chemotaxis

2001 ◽  
Vol 99 (1) ◽  
pp. 123-127 ◽  
Author(s):  
V. Sourjik ◽  
H. C. Berg
Keyword(s):  
Bacterial Chemotaxis ◽  
Receptor Sensitivity

Psychopathological Correlates of Reduced Dopamine Receptor Sensitivity in Depression, Schizophrenia, and Opiate and Alcohol Dependence12

2001 ◽  
Vol 34 (2) ◽  
pp. 66-72 ◽  
Author(s):  
K. Schmidt ◽  
B. Nolte-Zenker ◽  
J. Patzer ◽  
M. Bauer ◽  
L. G. Schmidt ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Receptor Sensitivity

scholarly journals Alterations by Norepinephrine of Cardiac Sympathetic Nerve Terminal Function and Myocardial β-Adrenergic Receptor Sensitivity in the Ferret

Circulation ◽  
2000 ◽  
Vol 102 (1) ◽  
pp. 96-103 ◽  
Author(s):  
Chang-seng Liang ◽  
Naomi Kenmotsu Rounds ◽  
Erdan Dong ◽  
Suzanne Y. Stevens ◽  
Junya Shite ◽  
...  
Keyword(s):  
Nerve Terminal ◽  
Sympathetic Nerve ◽  
Adrenergic Receptor ◽  
Cardiac Sympathetic Nerve ◽  
Receptor Sensitivity ◽  
Sympathetic Nerve Terminal

Epileptic psychoses and dopamine receptor sensitivity

1995 ◽  
Vol 37 (1) ◽  
pp. 64-65
Author(s):  
John G. Csernansky ◽  
Cynthia A. Csernansky
Keyword(s):  
Dopamine Receptor ◽  
Receptor Sensitivity
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