Exercise and Arachidonic Acid Metabolites: Effect of Adrenergic Beta Blockade

1983 ◽  
pp. 290-290 ◽  
Author(s):  
K. Laustiola ◽  
E. Seppälä ◽  
T. Nikkari ◽  
H. Vapaatalo
1983 ◽  
Vol 26 (1) ◽  
pp. 13-21 ◽  
Author(s):  
P. Kutsky ◽  
J.R. Falck ◽  
G.B. Weiss ◽  
S. Manna ◽  
N. Chacos ◽  
...  

1981 ◽  
Vol 55 (6) ◽  
pp. 877-883 ◽  
Author(s):  
Lennart Brandt ◽  
Bengt Ljunggren ◽  
Karl-Erik Andersson ◽  
Bengt Hindfelt ◽  
Tore Uski

✓ In small human cerebral arteries preincubated with indomethacin, contractions induced by cerebrospinal fluid (CSF), from patients with subarachnoid hemorrhage were markedly increased. Also contractions induced by noradrenaline, but not 5-hydroxytryptamine, were augmented. Prostacyclin and its metabolite 6-keto-prostaglandin (PG)E1 reversed the contractions induced by CSF, as well as by noradrenaline, 5-hydroxytryptamine, and PGF2α. The findings suggest that these substances are able to counteract the influence of vasoconstrictor material in hemorrhagic CSF. If the capacity to synthesize these “protective” arachidonic acid metabolites is reduced, the resulting imbalance between contractile and relaxant forces acting on the vessel wall may lead to sustained cerebral vasoconstriction.


1995 ◽  
Vol 16 (6) ◽  
pp. 396-402 ◽  
Author(s):  
Ivica Klapan ◽  
Filip Čulo ◽  
Josip Čulig ◽  
Željka Bukovec ◽  
Stjepan Simović ◽  
...  

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