An Introduction to the Study of Smoking Using Urinary Hydroxyproline

Author(s):  
H. Kasuga
Metabolism ◽  
1966 ◽  
Vol 15 (12) ◽  
pp. 1084-1091 ◽  
Author(s):  
N.G. Johnston ◽  
C.A. Lee ◽  
H.M. Lloyd

1981 ◽  
Vol 52 (3) ◽  
pp. 307-313 ◽  
Author(s):  
Lars B. Skogland ◽  
James A.A. Miller ◽  
Anna Skottner ◽  
Linda Fryklund

1964 ◽  
Vol 115 (1) ◽  
pp. 85-87 ◽  
Author(s):  
C. R. Jones ◽  
M. W. Bergman ◽  
P. J. Kittner ◽  
W. W. Pigman

1989 ◽  
Vol 66 (1) ◽  
pp. 14-19 ◽  
Author(s):  
K. H. Myburgh ◽  
T. D. Noakes ◽  
M. Roodt ◽  
F. S. Hough

The role of moderate exercise in the prevention of high-turnover osteoporosis was investigated by the use of an animal model. The effect of chronic training on gravimetric, mineral, physical, and histological parameters of normal bone was also examined. Fifty-six adult female Long-Evans rats were divided into four groups: sedentary (C) and exercising controls (E) and sedentary (O) and exercising osteoporotics (EO). Exercising animals ran 4 h/wk for 1 yr. Two percent NH4Cl added to drinking water induced osteoporosis as shown by significantly lower femoral density and breaking strength and histomorphometrically quantified tibial trabecular bone volume but a normal mineral-to-matrix ratio in the O rats. The development of high-turnover osteoporosis in O rats was confirmed by significantly higher alkaline phosphatase activity (P less than 0.05), urinary hydroxyproline content (P less than 0.01), resorption surfaces (P less than 0.01), and histological parameters of bone formation (P less than 0.01). Exercise prevented all these biochemical, biophysical, and histological abnormalities in the EO group. Exercise had no influence on the density of normal femurs but tended to increase their breaking strength (by 11%) compared with femurs of C rats (P = 0.11).


1978 ◽  
Vol 54 (1) ◽  
pp. 69-74 ◽  
Author(s):  
R. Wootton ◽  
J. Reeve ◽  
E. Spellacy ◽  
M. Tellez-Yudilevich

1. Blood flow to the skeleton was measured by the 18F clearance method of Wootton, Reeve & Veall (1976) in 24 patients with untreated Paget's disease. In every patient but one, resting skeletal blood flow was increased. There was a significant positive correlation between skeletal blood flow and serum alkaline phosphatase and between skeletal blood flow and urinary total hydroxyproline excretion. 2. Fourteen patients were re-studied after they had received short-term (7 days or less) or long-term (7 weeks or more) calcitonin. Skeletal blood flow, alkaline phosphatase and urinary hydroxyproline excretion fell towards normal in every case. There was some evidence from the short-term studies that calcitonin produced a more rapid fall in skeletal blood flow than in alkaline phosphatase. 3. Glomerular filtration rate appeared to increase transiently in response to calcitonin.


1970 ◽  
Vol 30 (3) ◽  
pp. 282-287 ◽  
Author(s):  
ROSEJOHN G. HADDAD ◽  
SANDRA COURANZ ◽  
LOUIS V. AVIOLP

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