scholarly journals Urinary hydroxyproline in children with growth hormone deficiency. Clinical value in diagnosis and prognosis.

1974 ◽  
Vol 49 (2) ◽  
pp. 159-162 ◽  
Author(s):  
B A Wharton ◽  
G Brown ◽  
P H Raynor ◽  
G Howells ◽  
C A Pennock
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Clinical Value ◽  
Urinary Hydroxyproline ◽  
Diagnosis And Prognosis

A novel diagnostic tool for the evaluation of hypothalamic-pituitary region and diagnosis of growth hormone deficiency: pons ratio

2020 ◽  
Vol 33 (6) ◽  
pp. 735-742
Author(s):  
Meliha Demiral ◽  
Mehmet Salih Karaca ◽  
Edip Unal ◽  
Birsen Baysal ◽  
Rıza Taner Baran ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Cost Benefit ◽  
Practical Method ◽  
Hormone Deficiency ◽  
Small Scale ◽  
Pituitary Hormone ◽  
Clinical Value ◽  
Pubertal Status ◽  
Sensitive Tool

AbstractBackgroundsLimitations in the evaluation of the pituitary size and changes according to pubertal status make its validity questionable. Recently, in a small-scale study, pons ratio (PR) has been suggested as a more sensitive tool for diagnosis and etiological evaluation of growth hormone deficiency (GHD). The aim of the study is to evaluate the diagnostic value of PR in the diagnosis of GHD.MethodsWe retrospectively evaluated the pituitary magnetic resonance imaging (MRI) of 133 patients with a diagnosis of GHD. Primary axis (PA) was assigned as a line crossing the mid-sagittal dorsum sella and fourth ventricle. PR was defined as the pons height above the PA divided by total pons height. The PR of patients with GHD was compared to subjects without GHD.ResultsStudy included 133 patients with GHD and 47 controls. In total, 121 (91%) patients had isolated GHD and 12 (9%) patients had multiple pituitary hormone deficiency. The PR of the patient group (mean: 0.32 ± 0.89; range: 0.14–0.63) was significantly higher than controls (mean: 0.26 ± 0.067; range 0.19–0.44) (p: 0.000). The optimal cut-off value of PR for GHD diagnosis was 0.27 (sensitivity 71% specificity 56%). There was a negative correlation between anterior pituitary height (APH)-SDS and PR (p: 0.002; r: −0.27). APH was increased, but PR remained unchanged in pubertal patients (p: 0.089).ConclusionsPR measurement is a noninvasive, practical method with a cost-benefit clinical value. As it is not affected by pubertal status, PR is potentially a more sensitive tool for evaluation of pituitary gland in GHD patients compared to APH.

Role of magnetic resonance imaging in the diagnosis and prognosis of growth hormone deficiency

1996 ◽  
Vol 45 (1) ◽  
pp. 21-26 ◽  
Author(s):  
M. Bozzola ◽  
C. Adamsbaum ◽  
I. Biscaldi ◽  
M. Zecca ◽  
M. Cisternino ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Growth Hormone ◽  
Magnetic Resonance ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Resonance Imaging ◽  
Diagnosis And Prognosis

scholarly journals Role of magnetic resonance imaging in the diagnosis and prognosis of growth hormone deficiency

1996 ◽  
Vol 45 (1) ◽  
pp. 21-26 ◽  
Author(s):  
M. Bozzola ◽  
C. Adamsbaum ◽  
I. Biscaldi ◽  
M. Zecca ◽  
M. Cisternino ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Growth Hormone ◽  
Magnetic Resonance ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Resonance Imaging ◽  
Diagnosis And Prognosis
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