Chemotactic Cytokine

2016 ◽  
pp. 956-956
Keyword(s):  
Inflammation ◽  
1992 ◽  
Vol 16 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Noriyasu Hirasawa ◽  
Masako Watanabe ◽  
Suetsugu Mue ◽  
Kazuyoshi Watanabe ◽  
Susumu Tsurufuji ◽  
...  

Blood ◽  
1998 ◽  
Vol 91 (6) ◽  
pp. 1909-1916 ◽  
Author(s):  
Amnon Peled ◽  
Jose Angel Gonzalo ◽  
Clare Lloyd ◽  
Jose-Carlos Gutierrez-Ramos

Abstract During inflammatory processes, inflamed tissues signal the bone marrow (BM) to produce more mature leukocytes in ways that are not yet understood. We report here that, during the development of lung allergic inflammation, the administration of neutralizing antibodies to the chemotactic cytokine, Eotaxin, prevented the increase in the number of myeloid progenitors produced in the BM, therefore reducing the output of mature myeloid cells from BM. Conversely, the in vivo administration of Eotaxin increased the number of myeloid progenitors present in the BM. Furthermore, we found that, in vitro, Eotaxin is a colony-stimulating factor for granulocytes and macrophages. Eotaxin activity synergized with stem cell factor but not with interleukin-3 or granulocyte-macrophage colony-stimulating factor and was inhibited bypertussis toxin. We report also that CCR-3, the receptor for Eotaxin, was expressed by hematopoietic progenitors (HP). Thus, during inflammation, Eotaxin acts in a paracrine way to shift the differentiation of BM HP towards the myeloid lineage.


1994 ◽  
Vol 725 (1) ◽  
pp. 91-103 ◽  
Author(s):  
JENS-MICHAEL SCHRöDER ◽  
YOSHIKAZU KAMEYOSHI ◽  
ENNO CHRISTOPHERS
Keyword(s):  

2007 ◽  
Vol 45 (3) ◽  
pp. 574-580 ◽  
Author(s):  
Rachel K. Middleton ◽  
Geraint M. Lloyd ◽  
Matthew J. Bown ◽  
Nicola J. Cooper ◽  
Nicholas J. London ◽  
...  

1994 ◽  
Vol 93 (3) ◽  
pp. 921-928 ◽  
Author(s):  
A E Koch ◽  
S L Kunkel ◽  
L A Harlow ◽  
D D Mazarakis ◽  
G K Haines ◽  
...  

1994 ◽  
Vol 94 (3) ◽  
pp. 1012-1018 ◽  
Author(s):  
A E Koch ◽  
S L Kunkel ◽  
L A Harlow ◽  
D D Mazarakis ◽  
G K Haines ◽  
...  
Keyword(s):  

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