Sparse Functional Linear Regression with Applications to Personalized Medicine

Author(s):  
Ian W. McKeague ◽  
Min Qian
Author(s):  
Hervé Cardot ◽  
Pascal Sarda

This article presents a selected bibliography on functional linear regression (FLR) and highlights the key contributions from both applied and theoretical points of view. It first defines FLR in the case of a scalar response and shows how its modelization can also be extended to the case of a functional response. It then considers two kinds of estimation procedures for this slope parameter: projection-based estimators in which regularization is performed through dimension reduction, such as functional principal component regression, and penalized least squares estimators that take into account a penalized least squares minimization problem. The article proceeds by discussing the main asymptotic properties separating results on mean square prediction error and results on L2 estimation error. It also describes some related models, including generalized functional linear models and FLR on quantiles, and concludes with a complementary bibliography and some open problems.


Author(s):  
Peter Hall

This article discusses the methodology and theory of principal component analysis (PCA) for functional data. It first provides an overview of PCA in the context of finite-dimensional data and infinite-dimensional data, focusing on functional linear regression, before considering the applications of PCA for functional data analysis, principally in cases of dimension reduction. It then describes adaptive methods for prediction and weighted least squares in functional linear regression. It also examines the role of principal components in the assessment of density for functional data, showing how principal component functions are linked to the amount of probability mass contained in a small ball around a given, fixed function, and how this property can be used to define a simple, easily estimable density surrogate. The article concludes by explaining the use of PCA for estimating log-density.


2009 ◽  
Vol 37 (5A) ◽  
pp. 2083-2108 ◽  
Author(s):  
Gareth M. James ◽  
Jing Wang ◽  
Ji Zhu

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