Synthesis of Diazirinyl Photophore and Optically Pure Diazirinylphenylalanines for Photoaffinity Labeling

2017 ◽  
pp. 111-128
Author(s):  
Yuta Murai ◽  
Lei Wang ◽  
Makoto Hashimoto
Keyword(s):  
Photoaffinity Labeling ◽  
Optically Pure

Alternative One-Pot Synthesis of (Trifluoromethyl)phenyldiazirines from Tosyloxime Derivatives: Application for New Synthesis of Optically Pure Diazirinylphenylalanines for Photoaffinity Labeling

2015 ◽  
Vol 17 (3) ◽  
pp. 616-619 ◽  
Author(s):  
Lei Wang ◽  
Yuta Murai ◽  
Takuma Yoshida ◽  
Akiko Ishida ◽  
Katsuyoshi Masuda ◽  
...  
Keyword(s):  
Photoaffinity Labeling ◽  
One Pot ◽  
One Pot Synthesis ◽  
New Synthesis ◽  
Optically Pure

Exploration of the peptide ligand-binding domain of the motilin receptor using photoaffinity labeling and receptor mutagenesis

2001 ◽  
Vol 120 (5) ◽  
pp. A509-A509
Author(s):  
B MATSUURA ◽  
M DONG ◽  
B COULIE ◽  
E HADAC ◽  
D PINON ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Photoaffinity Labeling ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Peptide Ligand ◽  
Motilin Receptor

A Peptoid with Extended Shape in Water

2019 ◽  
Author(s):  
Jumpei Morimoto ◽  
Yasuhiro Fukuda ◽  
Takumu Watanabe ◽  
Daisuke Kuroda ◽  
Kouhei Tsumoto ◽  
...  
Keyword(s):  
Spectroscopic Analysis ◽  
Dimensional Space ◽  
Three Dimensional ◽  
Biomolecular Recognition ◽  
Biological Application ◽  
New Class ◽  
Proteolytic Resistance ◽  
Pharmacokinetic Properties ◽  
Optically Pure ◽  
Three Dimensional Space

<div> <div> <div> <p>“Peptoids” was proposed, over decades ago, as a term describing analogs of peptides that exhibit better physicochemical and pharmacokinetic properties than peptides. Oligo-(N-substituted glycines) (oligo-NSG) was previously proposed as a peptoid due to its high proteolytic resistance and membrane permeability. However, oligo-NSG is conformationally flexible and is difficult to achieve a defined shape in water. This conformational flexibility is severely limiting biological application of oligo-NSG. Here, we propose oligo-(N-substituted alanines) (oligo-NSA) as a new peptoid that forms a defined shape in water. A synthetic method established in this study enabled the first isolation and conformational study of optically pure oligo-NSA. Computational simulations, crystallographic studies and spectroscopic analysis demonstrated the well-defined extended shape of oligo-NSA realized by backbone steric effects. The new class of peptoid achieves the constrained conformation without any assistance of N-substituents and serves as an ideal scaffold for displaying functional groups in well-defined three-dimensional space, which leads to effective biomolecular recognition. </p> </div> </div> </div>

scholarly journals Efficient conversion of hemicellulose sugars from spent sulfite liquor into optically pure L-lactic acid by Enterococcus mundtii

2021 ◽  
pp. 125215
Author(s):  
R. Hoheneder ◽  
E. Fitz ◽  
R.H. Bischof ◽  
H. Russmayer ◽  
P. Ferrero ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Efficient Conversion ◽  
Enterococcus Mundtii ◽  
Optically Pure ◽  
Spent Sulfite Liquor
Sign in / Sign up

Export Citation Format

Share Document