Therapeutic Hypothermia in Experimental Models of Traumatic Brain Injury

2000 ◽  
pp. 39-46 ◽  
Author(s):  
W. Dalton Dietrich
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Therapeutic Hypothermia ◽  
Experimental Models

Meta-Analysis of the Efficacy and Safety of Therapeutic Hypothermia in Children with Acute Traumatic Brain Injury

2015 ◽  
Vol 83 (4) ◽  
pp. 567-573 ◽  
Author(s):  
Bin-Fei Zhang ◽  
Jiao Wang ◽  
Zun-Wei Liu ◽  
Yong-Lin Zhao ◽  
Dan-Dong Li ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Therapeutic Hypothermia ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Acute Traumatic Brain Injury

Sirtuins, a potential target in Traumatic Brain Injury and relevant experimental models

2021 ◽  
Author(s):  
Niraja Ranadive ◽  
Devinder Arora ◽  
Madhavan Nampoothiri ◽  
Jayesh Mudgal
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Experimental Models ◽  
Potential Target

scholarly journals Large animal models of stroke and traumatic brain injury as translational tools

2018 ◽  
Vol 315 (2) ◽  
pp. R165-R190 ◽  
Author(s):  
Annabel J. Sorby-Adams ◽  
Robert Vink ◽  
Renée J. Turner
Keyword(s):  
Traumatic Brain Injury ◽  
Ischemic Stroke ◽  
Brain Injury ◽  
Animal Models ◽  
Animal Species ◽  
Experimental Models ◽  
Clinical Translation ◽  
Large Animal ◽  
Large Animal Models ◽  
Significant Burden

Acute central nervous system injury, encompassing traumatic brain injury (TBI) and stroke, accounts for a significant burden of morbidity and mortality worldwide. Studies in animal models have greatly enhanced our understanding of the complex pathophysiology that underlies TBI and stroke and enabled the preclinical screening of over 1,000 novel therapeutic agents. Despite this, the translation of novel therapeutics from experimental models to clinical therapies has been extremely poor. One potential explanation for this poor clinical translation is the choice of experimental model, given that the majority of preclinical TBI and ischemic stroke studies have been conducted in small animals, such as rodents, which have small lissencephalic brains. However, the use of large animal species such as nonhuman primates, sheep, and pigs, which have large gyrencephalic human-like brains, may provide an avenue to improve clinical translation due to similarities in neuroanatomical structure when compared with widely adopted rodent models. This purpose of this review is to provide an overview of large animal models of TBI and ischemic stroke, including the surgical considerations, key benefits, and limitations of each approach.

Experimental Models of Traumatic Brain Injury

2020 ◽  
pp. 24-33
Author(s):  
Ciaran S. Hill ◽  
Hiren C. Patel
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Experimental Models
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