A Conscious Animal Model for Studies of Coronary Collateral Blood Flow Dynamics

1990 ◽  
pp. 267-278 ◽  
Author(s):  
Dean Franklin ◽  
Atsushi Mikuniya ◽  
Masatoshi Fujita ◽  
Masaaki Takahashi ◽  
Michael McKown ◽  
...  
Keyword(s):  
Animal Model ◽  
Blood Flow ◽  
Flow Dynamics ◽  
Collateral Blood Flow ◽  
Coronary Collateral ◽  
Conscious Animal ◽  
Blood Flow Dynamics ◽  
Coronary Collateral Blood Flow

Hyperglycemia reduces coronary collateral blood flow through a nitric oxide-mediated mechanism

2001 ◽  
Vol 281 (5) ◽  
pp. H2097-H2104 ◽  
Author(s):  
Judy R. Kersten ◽  
Wolfgang G. Toller ◽  
John P. Tessmer ◽  
Paul S. Pagel ◽  
David C. Warltier
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Blood Glucose ◽  
Blood Glucose Concentration ◽  
Collateral Blood Flow ◽  
Coronary Collateral ◽  
Retrograde Blood Flow ◽  
Flow Through ◽  
Blood Glucose Concentrations ◽  
Coronary Collateral Blood Flow

We tested the hypothesis that hyperglycemia alters retrograde coronary collateral blood flow by a nitric oxide-mediated mechanism in a canine Ameriod constrictor model of enhanced collateral development. Administration of 15% dextrose to increase blood glucose concentration to 400 or 600 mg/dl decreased retrograde blood flow through the left anterior descending coronary artery to 78 ± 9 and 82 ± 8% of baseline values, respectively. In contrast, saline or l-arginine (400 mg · kg−1 · h−1) had no effect on retrograde flow. Coronary hypoperfusion and 1 h of reperfusion decreased retrograde blood flow similarly in saline- orl-arginine-treated dogs (76 ± 11 and 89 ± 4% of baseline, respectively), but these decreases were more pronounced in hyperglycemic dogs (47 ± 10%). l-Arginine prevented decreases in retrograde coronary collateral blood flow during hyperglycemia (100 ± 5 and 95 ± 6% of baseline at blood glucose concentrations of 400 and 600 mg/dl, respectively) and after coronary hypoperfusion and reperfusion (84 ± 14%). The results suggest that hyperglycemia decreases retrograde coronary collateral blood flow by adversely affecting nitric oxide availability.

scholarly journals Atrial natriuretic peptide augments coronary collateral blood flow: A study during coronary angioplasty

1998 ◽  
Vol 21 (10) ◽  
pp. 737-742 ◽  
Author(s):  
Zenon S. Kyriakides ◽  
Eftihia Sbarouni ◽  
Aias Antoniadis ◽  
Efstathios K. Iliodromitis ◽  
Dimitrios Mitropoulos ◽  
...  
Keyword(s):  
Blood Flow ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Coronary Angioplasty ◽  
Collateral Blood Flow ◽  
Coronary Collateral ◽  
Coronary Collateral Blood Flow ◽  
Atrial Natriuretic

scholarly journals Evaluation of Procedures Designed to Enhance Coronary Collateral Blood Flow

1962 ◽  
Vol 10 (2) ◽  
pp. 142-147 ◽  
Author(s):  
Robert M. Berne ◽  
Richard D. Jones ◽  
Frederick S. Cross
Keyword(s):  
Blood Flow ◽  
Collateral Blood Flow ◽  
Coronary Collateral ◽  
Coronary Collateral Blood Flow

Alterations of coronary collateral blood flow velocity during intraaortic balloon pumping

1993 ◽  
Vol 71 (16) ◽  
pp. 1451-1455 ◽  
Author(s):  
Michael S. Flynn ◽  
Morton J. Kern ◽  
Thomas J. Donohue ◽  
Frank V. Aguirre ◽  
Richard G. Bach ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Intraaortic Balloon ◽  
Collateral Blood Flow ◽  
Intraaortic Balloon Pumping ◽  
Coronary Collateral ◽  
Coronary Collateral Blood Flow
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