Reliability of Trust Management Systems in Cloud Computing

Cloud computing is an innovation that conveys administrations like programming, stage, and framework over the web. This computing structure is wide spread and dynamic, which chips away at the compensation per-utilize model and supports virtualization. Distributed computing is expanding quickly among purchasers and has many organizations that offer types of assistance through the web. It gives an adaptable and on-request administration yet at the same time has different security dangers. Its dynamic nature makes it tweaked according to client and supplier’s necessities, subsequently making it an outstanding benefit of distributed computing. However, then again, this additionally makes trust issues and or issues like security, protection, personality, and legitimacy. In this way, the huge test in the cloud climate is selecting a perfect organization. For this, the trust component assumes a critical part, in view of the assessment of QoS and Feedback rating. Nonetheless, different difficulties are as yet present in the trust the board framework for observing and assessing the QoS. This paper talks about the current obstructions present in the trust framework. The objective of this paper is to audit the available trust models. The issues like insufficient trust between the supplier and client have made issues in information sharing likewise tended to here. Besides, it lays the limits and their enhancements to help specialists who mean to investigate this point.

Histone chaperones exhibit conserved functionality in nucleosome remodeling

Chromatin homeostasis mediates some of the most fundamental processes in the eukaryotic cell. In this regard, histone chaperones have emerged as major regulatory factors during DNA replication, repair, and transcription. However, the dynamic nature of these processes has severely impeded their characterization at the molecular level. Here we apply single-molecule probing by fluorescence optical tweezers to follow histone chaperone dynamics in real-time. The molecular action of SET/template-activating factor-Iβ and nucleophosmin 1, representing the two most common histone chaperone folds, were examined using both nucleosomes and isolated core histones. We show that these chaperones present binding specificity for partially dismantled nucleosomes and are able to recognize and disrupt non-native histone-DNA interactions. Furthermore, we reveal that cytochrome c inhibition of histone chaperones is coupled to chaperone accumulation on DNA-bound histones. Our single-molecule approach shows that despite the drastically different structures of these chaperones, they present conserved modes of action mediating nucleosome remodeling.

Ten-year longitudinal investigation of astigmatism: The Yamagata Study (Funagata)

Despite numerous investigations into ocular or corneal astigmatism, the dynamic nature of astigmatism remains poorly understood. To reveal potential associations between age and astigmatism, 264 Japanese participants who underwent systemic and ophthalmological examinations in Funagata Town (Yamagata Prefecture, Japan) were evaluated over a 10-year period. Astigmatism was evaluated with regard to the cylinder power, cylinder axis, and vector analyses. Whereas the refractive cylinders showed age-related increases in patients in their 40s to 60s, the corneal cylinders did not change over 10 years. Nevertheless, cylindrical axis of the cornea demonstrated a continuous shift toward against-the-rule (ATR) astigmatism. Vector analyses revealed that the astigmatic shift toward ATR progressed continually after patients reached their 40s, although the shift did not accelerate with age. These novel insights may pave the way for the development of potential strategies for vision correction, including refractive surgeries, and vision-quality maintenance in the elderly.

Analysis of Dynamic Magnetoelastic Coupling in Mechanically Driven Magnetoelectric Antennas

Mechanically driven magnetoelectric antennas are a promising new technology that enable a reduction in antenna size by many orders of magnitude, as compared to conventional antennas. The magnetoelastic coupling in these antennas, a phenomenon playing a direct role in determining performance, has been modeled using approaches that are severely lacking in both accuracy and tractability. In response to this problem, we take a physics-based approach to the analysis of magnetoelastic coupling. We find that certain directions of applied stress will maximize the coupling and we derive general expressions to quantify it. Our results are applied in comprehensive simulations that demonstrate the dynamic nature of the coupling as well as the impact of various operating conditions and material properties. Our work contributes analytical expressions and associated insight that can serve not only as guidelines for the design of mechanically driven magnetoelectric antennas, but also as stepping stones towards the development of more accurate models.

Thematic analysis without paradox: sensemaking and context

Purpose In this paper, the authors underpin thematic analysis with a philosophical and methodological dimension and present a nuanced perspective on the application of thematic analysis in a data-driven context. Thematic analysis is a widely used qualitative analytic method; it is perceived as a transparent approach that offers single meaning. However, through Husserlian descriptive phenomenology, this paper aims to examine issues regarding subject/object and multidimensional meanings and realities. Design/methodology/approach In most extant studies, thematic analysis has become a prescriptive approach. This emerging qualitative approach has been applied to a range of studies on social and organisational issues, knowledge management and education. However, despite its wide usage, researchers are divided as to its effectiveness. Many choose quantitative approaches as an alternative, and some disagree as to what counts as the definitive framework and process for thematic analysis. Consequently, the authors provide a level of validity for thematic analysis through emphasising a specific methodological approach based on ontological and epistemological positions. Findings Contrary to the common mantra from contemporary qualitative researchers who claim thematic analysis is often based on a static and enduring approach, the current paper highlights the dynamic nature of a thematic analytic approach and offers a deeper understanding of the ways in which researchers can use the right approach to understand the emerging complex data context. Originality/value Several insights regarding the literature on thematic analysis were identified, including the current conceptualisation of thematic analysis as a dynamic approach. Understanding thematic analysis through phenomenology provides a basis on which to undertake a whole range of inclusive approaches that were previously undifferentiated from a quantitative perspective.

Development of OPLS-AA/M Parameters for Simulations of G Protein-Coupled Receptors and Other Membrane Proteins

G protein-coupled receptors (GPCRs) and other membrane proteins are valuable drug targets, and their dynamic nature makes them attractive systems for study with molecular dynamics simulations and free energy approaches. Here, we report the development, implementation, and validation of OPLS-AA/M force field parameters to enable simulations of these systems. These efforts include the introduction of post-translational modifications including lipidations and phosphorylation. We also modify previously reported parameters for lipids to be more consistent with the OPLS-AA force field standard and extend their coverage. These new parameters are validated on a variety of test systems, with the results compared to high-level quantum mechanics calculations, experimental data, and simulations with CHARMM36m where relevant. The results demonstrate that the new parameters reliably reproduce the behavior of membrane protein systems.

Conventional uroradiology with excretory urography: a forgotten art?

Excretory urography (EU) had been the most frequently performed imaging modality for uroradiology in the past. With the advances in Ultrasonography, and development of cross-sectional urography with Computed tomography (CT) and Magnetic resonance Imaging (MRI), EU is now seldom performed. Consequently, there has been a decline of expertise in this technique. However, EU has multiple advantages such as dynamic nature, easy availability, low cost and radiation burden. These render it potentially very valuable in specific indications like congenital anomalies, urothelial lesions and urinary leaks. This review intends to emphasize the current day relevance of excretory urography, outline the key points of the technique, and describe the pearls and pitfalls of interpretation.

Pathways to Developing Digital Capabilities within Entrepreneurial Initiatives in Pre-Digital Organizations

To enable new digital business models, pre-digital organizations launch entrepreneurial initiatives. However, in developing the required digital capabilities, pre-digital organizations often face challenges as they are marked by the ways they have historically established their organizational identity. Research on how pre-digital organizations can develop digital capabilities remains scarce. This study draws on a single case study to illustrate potential pathways for the development of digital capabilities. Two key characteristics are identified: the source of digital capability development and the set-up of the actors involved. The authors synthesize four possible pathway manifestations, discuss the dynamic nature of pathway combinations, and suggest that managing a portfolio of pathways may be crucial for pre-digital organizations. Therefore, the study contributes to a better understanding of digital transformation in pre-digital organizations. Furthermore, it provides guidance for practitioners to reflect on when deciding which pathways to follow.

Metaphors and Methods

It is widely understood that the development of a teacher identity for individuals transitioning into teaching is important, and therefore substantial research has been produced looking at teacher identity development. Much of this research is conducted using the possible selves theory as its framework. Nevertheless, with the self and identity being widely interpreted concepts with no consentaneous definition, researchers lean on metaphorical language at times to semantically represent the meaning of the future selves. This chapter reviews contemporary literature, discussing how different metaphors used to talk about the self, influence the methodological choices made within the study. Different types of metaphors used led to a heavier emphasis on either the integrative, temporal, or dynamic nature of the possible selves theory.

Hyper-Personalization

Personalization is widely used to attract and retain customers in online business addressing one size fits all issues, but little is addressed to contextualise users' real-time needs. E-commerce website owners use these strategies for customer-centric marketing through enhanced experience but fail in designing effective personalization due to the dynamic nature of users' needs and pace of information exposure. To address this, this chapter explores hyper-personalization strategies to overcome users' implicit need to be served better. The research presents a hyper-personalization process with learning (ML) and artificial intelligence (AI) techniques for marketing functions like segmentation, targeting, and positioning based on real-time analytics throughout the customer journey and key factors driving effective customer-centric marketing. This chapter facilitates marketers to use AI-enabled personalization to address customers' implicit needs and leverage higher returns by delivering the right information at the right time to the right customer through the right channel.