LH-RH Agonists in the Treatment of Premenopausal Patients with Advanced Breast Cancer

1992 ◽  
pp. 91-104 ◽  
Author(s):  
K. Höffken
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Advanced Breast ◽  
Premenopausal Patients ◽  
Lh Rh

Endocrine effects of combination antioestrogen and LH-RH agonist therapy in premenopausal patients with advanced breast cancer

1989 ◽  
Vol 25 (4) ◽  
pp. 651-654 ◽  
Author(s):  
Kerry J. Walker ◽  
Richard F. Walker ◽  
Atilla Turkes ◽  
John F.R. Robertson ◽  
Roger W. Blamey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Advanced Breast ◽  
Endocrine Effects ◽  
Agonist Therapy ◽  
Premenopausal Patients ◽  
Lh Rh

Phase ii trial of D-Trp-6-LH-RH in advanced breast cancer

1987 ◽  
Vol 28 ◽  
pp. 100
Author(s):  
G. Mathe ◽  
R. Helling ◽  
J. Gastlaburu ◽  
M.L.. VoVan ◽  
G. Prévot ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Advanced Breast ◽  
Lh Rh

Goserelin in Premenopausal Patients with Advanced Breast Cancer-A Multicenter Study

1998 ◽  
Vol 4 (2) ◽  
pp. 116-120
Author(s):  
Raquel Gerson ◽  
Victor Lira-Puerto ◽  
Ernesto Sanchez-Forgach ◽  
Maria Teresa Ramirez ◽  
Aura Erazo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Multicenter Study ◽  
Advanced Breast ◽  
Premenopausal Patients

Phase II trial of D-Trp-6-LH-RH in advanced breast cancer

1986 ◽  
Vol 22 (6) ◽  
pp. 723 ◽  
Author(s):  
G. Mathé ◽  
R. Kelling ◽  
M.L. VoVan ◽  
J. Gastiaburu ◽  
G. Prévot ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Advanced Breast ◽  
Lh Rh

Long-Term Response to Ovariectomy in 35 Premenopausal Patients with Advanced Breast Cancer, Treated in Coherence with Hormonal Tests

1983 ◽  
Vol 69 (4) ◽  
pp. 343-347 ◽  
Author(s):  
Ferdinando Preda ◽  
Sara Oriana ◽  
Giovanni Di Fronzo ◽  
Giorgio Secreto ◽  
Aldo Severini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Hormone Therapy ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Premenopausal Patients ◽  
Term Response ◽  
Actuarial Method

Thirty-five premenopausal patients with metastasized or locally advanced breast cancer underwent ovariectomy. At relapse, after surgery, they were treated with hormone therapy or chemotherapy, according to hormonal tests carried out before the castration. Five-year survival, computed with the actuarial method, confirmed the better prognosis of the hormone-dependent patients and also an improved prognosis in the patients treated with hormone therapy after ovariectomy. Furthermore, chemotherapy proved more efficacious: an increased survival was observed in the non-hormone-dependent patients.

Chemoimmunotherapy with or without oophorectomy in premenopausal patients with advanced breast cancer

1979 ◽  
Vol 12 (4) ◽  
pp. 333-341 ◽  
Author(s):  
Hwee-Yong Yap ◽  
Gabriel N. Hortobagyi ◽  
George R. Blumenschein ◽  
Charles K. Tashima ◽  
Aman U. Buzdar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Advanced Breast ◽  
Premenopausal Patients

Ovarian Function Suppression with the Gonadotrophin-Releasing Hormone (GnRH) Analogue Goserelin in Premenopausal Advanced Breast Cancer

1994 ◽  
Vol 80 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Emilio Bajetta ◽  
Luigi Celio ◽  
Nicoletta Zilembo ◽  
Aldo Bono ◽  
Domenico Galluzzo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Soft Tissues ◽  
Ovarian Function ◽  
Advanced Breast ◽  
Gnrh Analogue ◽  
Releasing Hormone ◽  
Ovarian Function Suppression ◽  
Premenopausal Patients ◽  
Gonadotrophin Releasing Hormone

Aims and background Goserelin is a gonadotrophin-releasing hormone (GnRH) analogue that induces the suppression of gonadal steroidogenesis, and it could therefore be a medical alternative to irreversible surgical castration. We report the clinical and endocrine results from 40 goserelin-treated premenopausal patients with advanced breast cancer. Methods A depot formulation of the drug (3.6 mg s.c.) was administered fortnightly for the first 4 doses, and monthly thereafter. Gonadotrophins and estradiol (E2) levels were measured before and at specific times during the treatment. Results Objective responses were observed in 17 of the 38 evaluable patients (45%), six of whom achieved complete remission. The best responses were observed on soft tissues (65%). Castration E2 levels were achieved in all of the patients. Conclusions Our results confirm that goserelin is as effective as surgical oophorectomy in premenopausal advanced breast cancer.

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