Hypercapnic Acidosis in Protective Mechanical Ventilation (a Tolerated Compromise or Another Means of Protection?)

2012 ◽  
pp. 93-106
Author(s):  
Biagio Allaria
Keyword(s):  
Mechanical Ventilation ◽  
Hypercapnic Acidosis ◽  
Protective Mechanical Ventilation

A review of intraoperative lung-protective mechanical ventilation strategy

2020 ◽  
Author(s):  
Trung kien Nguyen ◽  
Duc Hanh Mai ◽  
Anh Nguyet Le ◽  
Quang Huy Nguyen ◽  
Chi Tue Nguyen ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Ventilation Strategy ◽  
Protective Mechanical Ventilation ◽  
Lung Protective Mechanical Ventilation

scholarly journals Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Thiago G. Bassi ◽  
Elizabeth C. Rohrs ◽  
Karl C. Fernandez ◽  
Marlena Ornowska ◽  
Michelle Nicholas ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Brain Injury ◽  
Neuronal Damage ◽  
Normal Lung ◽  
Preclinical Model ◽  
Negative Consequences ◽  
Mechanically Ventilated ◽  
Protective Mechanical Ventilation ◽  
Hippocampal Apoptosis ◽  
Lung Protective Mechanical Ventilation

AbstractMechanical ventilation is the cornerstone of the Intensive Care Unit. However, it has been associated with many negative consequences. Recently, ventilator-induced brain injury has been reported in rodents under injurious ventilation settings. Our group wanted to explore the extent of brain injury after 50 h of mechanical ventilation, sedation and physical immobility, quantifying hippocampal apoptosis and inflammation, in a normal-lung porcine study. After 50 h of lung-protective mechanical ventilation, sedation and immobility, greater levels of hippocampal apoptosis and neuroinflammation were clearly observed in the mechanically ventilated group, in comparison to a never-ventilated group. Markers in the serum for astrocyte damage and neuronal damage were also higher in the mechanically ventilated group. Therefore, our study demonstrated that considerable hippocampal insult can be observed after 50 h of lung-protective mechanical ventilation, sedation and physical immobility.

scholarly journals Management of hypercapnia in critically ill mechanically ventilated patients—A narrative review of literature

2020 ◽  
Vol 21 (4) ◽  
pp. 327-333
Author(s):  
Ravindranath Tiruvoipati ◽  
Sachin Gupta ◽  
David Pilcher ◽  
Michael Bailey
Keyword(s):  
Mechanical Ventilation ◽  
Tidal Volume ◽  
Dead Space ◽  
Hypercapnic Acidosis ◽  
Mechanically Ventilated ◽  
Mechanically Ventilated Patients ◽  
Low Tidal Volume ◽  
Volume Ventilation ◽  
Low Volume ◽  
Ventilated Patients

The use of lower tidal volume ventilation was shown to improve survival in mechanically ventilated patients with acute lung injury. In some patients this strategy may cause hypercapnic acidosis. A significant body of recent clinical data suggest that hypercapnic acidosis is associated with adverse clinical outcomes including increased hospital mortality. We aimed to review the available treatment options that may be used to manage acute hypercapnic acidosis that may be seen with low tidal volume ventilation. The databases of MEDLINE and EMBASE were searched. Studies including animals or tissues were excluded. We also searched bibliographic references of relevant studies, irrespective of study design with the intention of finding relevant studies to be included in this review. The possible options to treat hypercapnia included optimising the use of low tidal volume mechanical ventilation to enhance carbon dioxide elimination. These include techniques to reduce dead space ventilation, and physiological dead space, use of buffers, airway pressure release ventilation and prone positon ventilation. In patients where hypercapnic acidosis could not be managed with lung protective mechanical ventilation, extracorporeal techniques may be used. Newer, minimally invasive low volume venovenous extracorporeal devices are currently being investigated for managing hypercapnia associated with low and ultra-low volume mechanical ventilation.

Effectiveness Of Protective Mechanical Ventilation In Acute Lung Injury In Septic Patients

2011 ◽  
Author(s):  
Ricard Ferrer ◽  
Antoni Artigas ◽  
Mitchell Levy ◽  
Maria Luisa Martinez ◽  
Candelaria de Haro ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Protective Mechanical Ventilation

Protective mechanical ventilation during general anaesthesia

2013 ◽  
Vol 3 (2) ◽  
pp. 77-81 ◽  
Author(s):  
Maria Vargas ◽  
Iole Brunetti ◽  
Paolo Pelosi
Keyword(s):  
Mechanical Ventilation ◽  
General Anaesthesia ◽  
Protective Mechanical Ventilation

Protective mechanical ventilation in the obese patient

2020 ◽  
Vol 58 (3) ◽  
pp. 53-57
Author(s):  
Luiz F.d.R. Falcão ◽  
Paolo Pelosi ◽  
Marcelo Gama de Abreu
Keyword(s):  
Mechanical Ventilation ◽  
Obese Patient ◽  
Protective Mechanical Ventilation
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