Inhibitory effects of cyclosporin A on lymphocyte activation

Cyclosporin ◽  
1989 ◽  
pp. 1-23 ◽  
Author(s):  
John E. Kay
Keyword(s):  
Cyclosporin A ◽  
Lymphocyte Activation ◽  
Inhibitory Effects

Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location

1993 ◽  
Vol 13 (8) ◽  
pp. 4760-4769
Author(s):  
R J Bram ◽  
D T Hung ◽  
P K Martin ◽  
S L Schreiber ◽  
G R Crabtree
Keyword(s):  
Signal Transduction ◽  
T Cell ◽  
Cyclosporin A ◽  
Cell Function ◽  
Inhibitory Effects ◽  
Gene Deletions ◽  
Cyclophilin B ◽  
Intracellular Vesicles

The immunosuppressants cyclosporin A (CsA) and FK506 appear to block T-cell function by inhibiting the calcium-regulated phosphatase calcineurin. While multiple distinct intracellular receptors for these drugs (cyclophilins and FKBPs, collectively immunophilins) have been characterized, the functionally active ones have not been discerned. We found that overexpression of cyclophilin A or B or FKBP12 increased T-cell sensitivity to CsA or FK506, respectively, demonstrating that they are able to mediate the inhibitory effects of their respective immunosuppressants in vivo. In contrast, cyclophilin C, FKBP13, and FKBP25 had no effect. Direct comparison of the Ki of each drug-immunophilin complex for calcineurin in vitro revealed that although calcineurin binding was clearly necessary, it was not sufficient to explain the in vivo activity of the immunophilin. Subcellular localization was shown also to play a role, since gene deletions of cyclophilins B and C which changed their intracellular locations altered their activities significantly. Cyclophilin B has been shown previously to be located within calcium-containing intracellular vesicles; its ability to mediate CsA inhibition implies that certain components of the signal transduction machinery are also spatially restricted within the cell.

scholarly journals Difference in Inhibitory Effects of Dexamethasone and Cyclosporin A on Sephadex Bead-Induced Airway Hyperresponsiveness and Inflammation in Rats

1998 ◽  
Vol 77 (1) ◽  
pp. 89-98 ◽  
Author(s):  
Shigeki Matsubara ◽  
Keiko Fushimi ◽  
Hideo Kikkawa ◽  
Kazuaki Naito ◽  
Katsuo Ikezawa
Keyword(s):  
Cyclosporin A ◽  
Airway Hyperresponsiveness ◽  
Inhibitory Effects ◽  
Sephadex Bead

Long-lasting Inhibitory Effects of Cyclosporin A, but Not Tacrolimus, on OATP1B1- and OATP1B3-mediated Uptake

2012 ◽  
Vol 27 (4) ◽  
pp. 368-378 ◽  
Author(s):  
Yoshihisa Shitara ◽  
Kumiko Takeuchi ◽  
Yoshiko Nagamatsu ◽  
Satomi Wada ◽  
Yuichi Sugiyama ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Inhibitory Effects

Growth inhibitory effects of FK506 and cyclosporin A independent of inhibition of calcineurin

1995 ◽  
Vol 49 (3) ◽  
pp. 367-373 ◽  
Author(s):  
A. Richter ◽  
D.E. Davies ◽  
P. Alexander
Keyword(s):  
Cyclosporin A ◽  
Inhibitory Effects ◽  
Growth Inhibitory

Immediate Early Genes of Cytomegalovirus Antagonize the Inhibitory Effects of Cyclosporin A on lnterleukin-2 Gene Transcription

CHEST Journal ◽  
1993 ◽  
Vol 103 (2) ◽  
pp. 133S-134S ◽  
Author(s):  
Lois J. Geist ◽  
Martha Monick ◽  
Mark Stinski ◽  
Gary Hunninghake
Keyword(s):  
Cyclosporin A ◽  
Gene Transcription ◽  
Immediate Early Genes ◽  
Immediate Early ◽  
Inhibitory Effects ◽  
Early Genes

scholarly journals In Vitro Effects of Ginkgolide B on Lymphocyte Activation in Atopic Asthma. Comparison With Cyclosporin A.

2000 ◽  
Vol 83 (3) ◽  
pp. 241-245 ◽  
Author(s):  
Fadia Mahmoud ◽  
Habib Abul ◽  
Babatunde Onadeko ◽  
Mousa Khadadah ◽  
Donald Haines ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Lymphocyte Activation ◽  
Atopic Asthma ◽  
Ginkgolide B ◽  
In Vitro Effects

Studies on the Mechanism whereby Cyclosporin A Inhibits T-Lymphocyte Activation

Immunobiology ◽  
1985 ◽  
Vol 169 (1) ◽  
pp. 83-96 ◽  
Author(s):  
M. Stoeck ◽  
K. Wildhagen ◽  
Marta Szamel ◽  
D. Lovett ◽  
K. Resch
Keyword(s):  
Cyclosporin A ◽  
T Lymphocyte ◽  
Lymphocyte Activation ◽  
T Lymphocyte Activation
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