Cyclosporin A and bone marrow transplantation

Cyclosporin ◽  
1989 ◽  
pp. 145-158
Author(s):  
Kerry Atkinson
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Cyclosporin A ◽  
Marrow Transplantation

Hypertriglyceridemia: Apheretic Treatment

2005 ◽  
Vol 28 (10) ◽  
pp. 1018-1024 ◽  
Author(s):  
G. Giannini ◽  
M. Valbonesi ◽  
F. Morelli ◽  
P. Carlier ◽  
M.C. De Luigi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Pancreatitis ◽  
Bone Marrow Transplantation ◽  
High Risk ◽  
Cyclosporin A ◽  
Marrow Transplantation ◽  
Removal Rate ◽  
The Other ◽  
Two Factors ◽  
High Triglyceride

Patients with extremely high triglyceride levels and associated lipemia are at high risk for acute pancreatitis. Two factors can increase triglyceride-rich lipoproteins; one is overproduction and other is a defect in clearance. Either mechanism can cause hypertriglyceridemia and both may exist simultaneously. Causes can be either primary or secondary. Plasmapheresis is efficacious for severe hypertryceridemia in patients who have not responded to previous therapies. We have treated 15 cases of hypertrygliceridemia complicating the course of patients receiving Cyclosporin A after bone marrow transplantation. Five patients were treated with plasmapheresis, the other ten with cascade filtration. The removal rate for triglycerides was 58.0% for patients treated by cascade filtration and 63.5% for patients treated by plasmapheresis. The removal rates for triglycerides were low possibly as a consequence of early saturation of the filter.

scholarly journals Influence of cytarabine and cyclophosphamide on the disposition kinetics of cyclosporin A after bone marrow transplantation

2003 ◽  
Vol 16 (11) ◽  
pp. 788-793
Author(s):  
Tsutomu Shimada ◽  
Yuki Aoki ◽  
Koichi Yokogawa ◽  
Masaaki Nomura ◽  
Junko Ishizaki ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Cyclosporin A ◽  
Marrow Transplantation ◽  
Disposition Kinetics ◽  
Kinetics Of

Use of cyclosporin A in allogeneic bone marrow transplantation in the rat

Nature ◽  
1979 ◽  
Vol 280 (5718) ◽  
pp. 148-151 ◽  
Author(s):  
PETER J. TUTSCHKA ◽  
WILLIAM E. BESCHORNER ◽  
ANTHONY C. ALLISON ◽  
WILLIAM H. BURNS ◽  
GEORGE W. SANTOS
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Cyclosporin A ◽  
Marrow Transplantation ◽  
Allogeneic Bone Marrow Transplantation ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone

Plasma Exchange for the Management of Cyclosporin A-Induced Hypertriglyceridemia

1988 ◽  
Vol 11 (3) ◽  
pp. 209-211 ◽  
Author(s):  
M. Valbonesi ◽  
D. Occhini ◽  
C. Capra ◽  
R. Frisoni ◽  
M. Fella ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Cyclosporin A ◽  
Disease Progression ◽  
Plasma Exchange ◽  
Triglyceride Level ◽  
Clinical Picture ◽  
Marrow Transplantation ◽  
Plasma Triglyceride ◽  
Plasma Triglyceride Level

The Authors report a case of hypertriglyceridemia complicating the course of a patient receiving cyclosporin A after bone marrow transplantation. When the patient was seen at the hemapheresis unit the clinical picture was characterized by headache, increasing visual and neurological disturbances. Plasma triglyceride level was 3215 mg/dl. Two plasma exchange sessions reduced triglycerides to 486 mg/dl and halted the disease progression. This may represent the first plasma exchange treatment of cyclosporin A-induced hypertriglyceridemia.

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