A Survey of the Experimental Literature on the B-Fe-Nd System and Related Topics

1989 ◽  
pp. 53-62
Author(s):  
V. G. Rivlin ◽  
A. P. Miodownik
Keyword(s):  
Experimental Literature

Toward a Comprehensive Treatment of Tautomerism in Chemoinformatics Including in InChI V2

2019 ◽  
Author(s):  
Devendra K. Dhaked ◽  
Wolf Ihlenfeldt ◽  
Hitesh Patel ◽  
Marc Nicklaus
Keyword(s):  
Small Molecule ◽  
Comprehensive Treatment ◽  
Experimental Literature ◽  
Web Tool ◽  
Valence Tautomerism ◽  
Standard Version ◽  
Small Molecule Databases

<p>We have collected 86 different transforms of tautomeric interconversions. Out of those, 54 are for prototropic (non-ring-chain) tautomerism; 21 for ring-chain tautomerism; and 11 for valence tautomerism. The majority of these rules have been extracted from experimental literature. Twenty rules – covering the most well-known types of tautomerism such as keto-enol tautomerism – were taken from the default handling of tautomerism by the chemoinformatics toolkit CACTVS. The rules were analyzed against nine differerent databases totaling over 400 million (non-unique) structures as to their occurrence rates, mutual overlap in coverage, and recapitulation of the rules’ enumerated tautomer sets by InChI V.1.05, both in InChI’s Standard and a Non-Standard version with the increased tautomer-handling options 15T and KET turned on. These results and the background of this study are discussed in the context of the IUPAC InChI Project tasked with the redesign of handling of tautomerism for an InChI version 2. Applying the rules presented in this paper would approximately triple the number of compounds in typical small-molecule databases that would be affected by tautomeric interconversion by InChI V2. A web tool has been created to test these rules at https://cactus.nci.nih.gov/tautomerizer.</p>

Biochemical and Morphological Validation of a Rodent Model of Organophosphorus-Induced Delayed Neuropathy

1988 ◽  
Vol 4 (3) ◽  
pp. 361-371 ◽  
Author(s):  
Stephanie Padilla ◽  
Bellina Veronesi
Keyword(s):  
Data Base ◽  
Experimental Model ◽  
Nerve Fibers ◽  
Rodent Model ◽  
Experimental Literature ◽  
Delayed Neuropathy

Exposure to certain organophosphates (OPs) produces a delayed degeneration of the longest and largest nerve fibers (OPIDN). Until recently, investigators have used the chicken as the primary experimental model of OPIDN. Although the chicken is extremely sensitive to the ataxia associated with this neuropathy, it lacks an extensive biochemical, electrophysiological and pathological data-base. Because of this we set out to develop a rodent model of OPIDN with morphological and biochemical correlates similar to those seen in the chicken. Historically the rat had been labeled insensitive to OPIDN because of its lack of demonstrable ataxia in response to the neuropathic OPs. This paper describes the validation of a rodent model with biochemical and morphological endpoints similar to those described in the clinical and experimental literature for other models of OPIDN.

Improving Drug Prescribing in Primary Care: A Critical Analysis of the Experimental Literature

1989 ◽  
Vol 67 (2) ◽  
pp. 268 ◽  
Author(s):  
Stephen B. Soumerai ◽  
Thomas J. McLaughlin ◽  
Jerry Avorn
Keyword(s):  
Primary Care ◽  
Critical Analysis ◽  
Experimental Literature ◽  
Drug Prescribing

Modernismo’s Literary Engagements with Film

2018 ◽  
pp. 181-207
Author(s):  
Maite Conde
Keyword(s):  
Experimental Literature ◽  
Brazilian Literature ◽  
Mario De Andrade ◽  
Avant Garde ◽  
Literary Movement ◽  
Art Form ◽  
New Ideas ◽  
Film Form

By the 1920s, new ideas regarding film as the seventh art disseminated in Europe had a profound effect on Brazilian literature, specifically the emergence of an avant-garde literary movement known as modernismo, or “modernism.” Charting the new theories regarding cinema as an art form, this chapter examines how they were appropriated and elaborated by modernist writers in Brazil in the 1920s, most notably in the novels of Oswald de Andrade, the poetry of Mário de Andrade, and an urban chronicle by Antônio de Alcântara Machado called Pathé Baby. In examining this experimental literature, the chapter shows how new international ideas regarding film form and aesthetics provided the modernist writers with a tool for critiquing the official trajectory of national modernity in Brazil.

Reading experimental literature:

Reading Today ◽  
2018 ◽  
pp. 15-30
Author(s):  
Natalya Bekhta
Keyword(s):  
Experimental Literature
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