Antibody-secreting cell responses after vaccination with parenteral killed, oral killed or oral live vaccine

1990 ◽  
pp. 353-354
Author(s):  
A Kantele ◽  
H Arvilommi ◽  
A Ratilainen ◽  
L Rintala ◽  
J M Kantele ◽  
...  
2016 ◽  
Vol 10 (6) ◽  
pp. e0004753 ◽  
Author(s):  
Wilfredo R. Matias ◽  
Brie Falkard ◽  
Richelle C. Charles ◽  
Leslie M. Mayo-Smith ◽  
Jessica E. Teng ◽  
...  

AIDS ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Eduardo L.V. Silveira ◽  
Jung Joo Hong ◽  
Praveen K. Amancha ◽  
Kenneth A. Rogers ◽  
Aftab A. Ansari ◽  
...  

2001 ◽  
Vol 39 (8) ◽  
pp. 2807-2813 ◽  
Author(s):  
K. O. Chang ◽  
O. H. Vandal ◽  
L. Yuan ◽  
D. C. Hodgins ◽  
L. J. Saif

2013 ◽  
Vol 20 (10) ◽  
pp. 1592-1598 ◽  
Author(s):  
Atiqur Rahman ◽  
Rasheduzzaman Rashu ◽  
Taufiqur Rahman Bhuiyan ◽  
Fahima Chowdhury ◽  
Ashraful Islam Khan ◽  
...  

ABSTRACTInfection withVibrio choleraeand oral cholera vaccines (OCVs) induce transient circulating plasmablast responses that peak within approximately 7 days after infection or vaccination. We previously demonstrated that plasmablast responses strongly correlate with subsequent levels ofV. cholerae-specific duodenal antibodies up to 6 months afterV. choleraeinfection. Hence, plasmablast responses provide an early window into the immunologic memory at the mucosal surface. In this study, we characterized plasmablast responses followingV. choleraeinfection using a flow cytometrically defined population and comparedV. cholerae-specific responses in adult patients withV. choleraeO1 infection and vaccinees who received the OCV Dukoral (Crucell Vaccines Canada). Among flow cytometrically sorted populations of gut-homing plasmablasts, almost 50% of the cells recognized either cholera toxin B subunit (CtxB) orV. choleraeO1 lipopolysaccharide (LPS). Using a traditional enzyme-linked immunosorbent spot assay (ELISPOT), we found that infection withV. choleraeO1 and OCVs induce similar responses to the protein antigen CtxB, but responses to LPS were diminished after OCV compared to those after naturalV. choleraeinfection. A second dose of OCV on day 14 failed to boost circulatingV. cholerae-specific plasmablast responses in Bangladeshi adults. Our results differ from those in studies from areas where cholera is not endemic, in which a second vaccination on day 14 significantly boosts plasmablast responses. Given these results, it is likely that the optimal boosting strategies for OCVs differ significantly between areas whereV. choleraeinfection is endemic and those where it is not.


2012 ◽  
Vol 16 ◽  
pp. e224
Author(s):  
C. Jones ◽  
C. Waddington ◽  
T. Darton ◽  
J. Bowman ◽  
J. Farrar ◽  
...  

Vaccine ◽  
2003 ◽  
Vol 21 (19-20) ◽  
pp. 2492-2499 ◽  
Author(s):  
Maria Pihlgren ◽  
Chantal Tougne ◽  
Nadine Schallert ◽  
Paola Bozzotti ◽  
Paul-Henri Lambert ◽  
...  

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