Factor VIII — structure and function

1982 ◽  
pp. 159-172
Author(s):  
L. Hoyer
Keyword(s):  
Factor Viii ◽  
Structure And Function ◽  
And Function

Factor VIII: Structure and function in blood clotting

1984 ◽  
Vol 16 (3) ◽  
pp. 297-306 ◽  
Author(s):  
Stephen I. Chavin
Keyword(s):  
Factor Viii ◽  
Blood Clotting ◽  
Structure And Function ◽  
And Function

The Life Cycle of Coagulation Factor VIII in View of Its Structure and Function

Blood ◽  
1998 ◽  
Vol 92 (11) ◽  
pp. 3983-3996 ◽  
Author(s):  
Peter J. Lenting ◽  
Jan A. van Mourik ◽  
Koen Mertens
Keyword(s):  
Life Cycle ◽  
Factor Viii ◽  
Coagulation Factor ◽  
Structure And Function ◽  
Coagulation Factor Viii ◽  
And Function

Factor VIII Structure and Function

1993 ◽  
Vol 70 (01) ◽  
pp. 063-067 ◽  
Author(s):  
Philip J Fay
Keyword(s):  
Factor Viii ◽  
Structure And Function ◽  
And Function

Factor VIII Structure and Function

2006 ◽  
Vol 83 (2) ◽  
pp. 103-108 ◽  
Author(s):  
Philip Fay
Keyword(s):  
Factor Viii ◽  
Structure And Function ◽  
And Function

scholarly journals Heterogeneity of autoantibodies to factor VIII: differences in specificity for apparently distinct antigenic determinants of factor VIII coagulant protein

Blood ◽  
1983 ◽  
Vol 62 (1) ◽  
pp. 133-140 ◽  
Author(s):  
MP Croissant ◽  
M Zuzel ◽  
JP Allain
Keyword(s):  
Factor Viii ◽  
Protein A ◽  
Structure And Function ◽  
Selective Recognition ◽  
Antigenic Determinants ◽  
Immunoradiometric Assay ◽  
Naturally Occurring ◽  
Response Slope ◽  
And Function ◽  
Naturally Occurring Antibodies

The interference of antibodies to factor VIII coagulant protein (VIII:C) of 9 nonhemophilic patients with the binding to factor VIII coagulant antigen (VIII:CAg) of a reference hemophilic 125I-Fab' reagent, used in a liquid phase VIII:CAg assay, was studied. The binding competition was estimated from immunoradiometric assay (IRMA) dose-response slope of VIII:CAg present in patient plasma, interference of antibodies with the 125I-Fab' binding to VIII:CAg in normal plasma, and the displacement of antibody from the complexes with VIII:CAg by the 125I Fab'. Antibody populations from three patients were studied in detail; in the VIII:CAg assay, two of them interfered with the 125I- Fab' binding, and one did not (patient 1). The formation of stable complexes between antibodies of each patient and VIII:CAg was demonstrated by protein-A-Sepharose adsorption. The 125I-Fab' binding to VIII:CAg-anti-VIII:CAg IgG complexes indicated that patient 1 antibodies and the 125I-Fab' recognized different antigenic determinants, whereas the other two patient antibodies and 125I-Fab' recognized closely related or identical VIII:CAg determinants. These results demonstrate an apparently selective recognition of at least two distinct VIII:CAg determinants by naturally occurring antibodies, suggesting a possibility of a wider use of these antibodies in studies of the structure and function of factor VIII.

Subunit Structure and Function of Porcine Factor Xa-Activated Factor VIII†

Biochemistry ◽  
1997 ◽  
Vol 36 (31) ◽  
pp. 9365-9373 ◽  
Author(s):  
Ernest T. Parker ◽  
Jan Pohl ◽  
Michael N. Blackburn ◽  
Pete Lollar
Keyword(s):  
Factor Viii ◽  
Factor Xa ◽  
Structure And Function ◽  
Subunit Structure ◽  
And Function
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