Selective Recognition
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Polymers ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 175
Jiawei Li ◽  
Xinji Zhou ◽  
Yu Yan ◽  
Dianling Shen ◽  
Danqing Lu ◽  

Gallic acid is widely used in the field of food and medicine due to its diversified bioactivities. The extraction method with higher specificity and efficiency is the key to separate and purify gallic acid from complex biological matrix. Herein, using self-made core-shell magnetic molecularly imprinted polymers (MMIP) with gallic acid as template, a hollow magnetic molecularly imprinted polymer (HMMIP) with double imprinting/adsorption surfaces was prepared by etching the mesoporous silica intermediate layer of MMIP. The characterization and adsorption research showed that the HMMIP had larger specific surface area, higher magnetic response strength and a more stable structure, and the selectivity and saturated adsorption capacity (2.815 mmol/g at 318 K) of gallic acid on HMMIP were better than those of MMIP. Thus, in addition to MMIP, the improved HMMIP had excellent separation and purification ability to selectively extract gallic acid from complex matrix with higher specificity and efficiency.

Chemosensors ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 2
Aleksandra Kalinowska ◽  
Magdalena Wicik ◽  
Patrycja Matusiak ◽  
Patrycja Ciosek-Skibińska

Differential sensing techniques are becoming nowadays an attractive alternative to classical selective recognition methods due to the “fingerprinting” possibility allowing identifying various analytes without the need to fabricate highly selective binding recognition sites. This work shows for the first time that surfactant-based ion-sensitive microspheres as optodes in the microscale can be designed as cross-sensitive materials; thus, they are perfect candidates as sensing elements for differential sensing. Four types of the newly developed chemosensory microspheres—anion- and cation-selective, sensitive toward amine- and hydroxyl moiety—exhibited a wide range of linear response (two to five orders of magnitude) in absorbance and/or fluorescence mode, great time stability (at least 2 months), as well as good fabrication repeatability. The array of four types of chemosensitive microspheres was capable of perfect pattern-based identification of eight neurotransmitters: dopamine, epinephrine, norepinephrine, γ-aminobutyric acid (GABA), acetylcholine, histamine, taurine, and phenylethylamine. Moreover, it allowed the quantification of neurotransmitters, also in mixtures. Its selectivity toward neurotransmitters was studied using α- and β-amino acids (Ala, Asp, Pro, Tyr, taurine) in simulated blood plasma solution. It was revealed that the chemosensory optode set could recognize subtle differences in the chemical structure based on the differential interaction of microspheres with various moieties present in the molecule. The presented method is simple, versatile, and convenient, and it could be adopted to various quantitative and qualitative analytical tasks due to the simple adjusting of microspheres components and measurement conditions.

Sahana Vasudevan ◽  
Parthasarathy Srinivasan ◽  
Prasanna Neelakantan ◽  
John Bosco Balaguru Rayappan ◽  
Adline Princy Solomon

Currently available diagnostic procedures for infections are laborious and time-consuming, resulting in a substantial financial burden by increasing morbidity, increased costs of hospitalization, and mortality. Therefore, innovative approaches to design diagnostic biomarkers are imperative to assist in the rapid and sensitive diagnosis of microbial infections. Acyl homoserine lactones (AHLs) are ubiquitous bacterial signaling molecules that are found to be significantly upregulated in infected sites. In this pioneering work, we have developed a simple photoluminescence-based assay using cysteamine-capped titanium oxide (TiO2) nanoparticles for AHL detection. The PL intensity variation of the oxygen defect state of TiO2 was used for the biosensing measurements. The bioassays were validated using two well-studied AHL molecules (C4-HSL and 3-oxo-C12 HSL) of an important human pathogen, Pseudomonas aeruginosa. The developed system has a maximum relative response of 98%. Furthermore, the efficacy of the system in simulated host urine using an artificial urine medium showed a linear detection range of 10–160 nM. Also, we confirmed the relative response and specificity of the system in detecting AHLs produced by P. aeruginosa in a temporal manner.

2021 ◽  
pp. 339334
María Vergara-Barberán ◽  
María Jesús Lerma-García ◽  
Ernesto F. Simó-Alfonso ◽  
Marta García-Hernández ◽  
M. Elena Martín ◽  

2021 ◽  
Vol 8 (12) ◽  
Jun Zheng ◽  
Lian An ◽  
Jie Gao ◽  
Lin Zhang ◽  
Xinan Yang ◽  

This paper has selected dicyclohexanocucurbit[6]uril (CyH 2 Q[6]) as the host and 2-phenylbenzimidazole ( G ) as the guest to investigate the host–guest interaction mode between CyH 2 Q[6] and G . Under acidic conditions, the complex was characterized using nuclear magnetic resonance, ultraviolet and fluorescence spectroscopy. The results show that the molecular ratio of CyH 2 Q[6] to G is 2 : 1. The crystals were cultured with ZnCl 2 as a structural inducer under acidic conditions and single crystal X-ray diffraction showed that the molecular ratio of CyH 2 Q[6] to G is 1 : 3. The [email protected] 2 Q[6] was used as a fluorescent probe to identify metal cations. The probe exhibits a good selective recognition effect toward Fe 3+ ions, which involves a reduced fluorescence intensity with a limit of detection of 1.321 × 10 –6 mol l –1 .

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