Interference by Domperidone on Chemosensory and Ventilatory Responses to Dopamine

1987 ◽  
pp. 322-333
Author(s):  
P. Zapata ◽  
F. Torrealba
Keyword(s):  
Ventilatory Responses ◽  
Responses To Dopamine

Contribution of Muscle Afferents to the Hemodynamic, Autonomic, and Ventilatory Responses to Exercise in Patients With Chronic Heart Failure

Circulation ◽  
1996 ◽  
Vol 93 (5) ◽  
pp. 940-952 ◽  
Author(s):  
Massimo Piepoli ◽  
Andrew L. Clark ◽  
Maurizio Volterrani ◽  
Stamatis Adamopoulos ◽  
Peter Sleight ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Muscle Afferents ◽  
Ventilatory Responses

Differential Human Renal Tubular Responses to Dopamine Type 1 Receptor Stimulation Are Determined by Blood Pressure Status

Hypertension ◽  
1997 ◽  
Vol 29 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Damian P. O'Connell ◽  
N. Virginia Ragsdale ◽  
David G. Boyd ◽  
Robin A. Felder ◽  
Robert M. Carey
Keyword(s):  
Blood Pressure ◽  
Receptor Stimulation ◽  
Responses To Dopamine ◽  
Renal Tubular

scholarly journals Altered dopaminergic firing pattern and novelty response underlie ADHD-like behavior of SorCS2-deficient mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ditte Olsen ◽  
Niels Wellner ◽  
Mathias Kaas ◽  
Inge E. M. de Jong ◽  
Florence Sotty ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Firing Pattern ◽  
Neurodevelopmental Disorder ◽  
Paradoxical Response ◽  
Dopaminergic Transmission ◽  
Hyperactivity Disorder ◽  
Responses To Dopamine ◽  
Circuit Function ◽  
Underlying Pathophysiology

AbstractAttention deficit hyperactivity disorder (ADHD) is the most frequently diagnosed neurodevelopmental disorder worldwide. Affected individuals present with hyperactivity, inattention, and cognitive deficits and display a characteristic paradoxical response to drugs affecting the dopaminergic system. However, the underlying pathophysiology of ADHD and how this relates to dopaminergic transmission remains to be fully understood. Sorcs2−/− mice uniquely recapitulate symptoms reminiscent of ADHD in humans. Here, we show that lack of SorCS2 in mice results in lower sucrose intake, indicating general reward deficits. Using in-vivo recordings, we further find that dopaminergic transmission in the ventral tegmental area (VTA) is shifted towards a more regular firing pattern with marked reductions in the relative occurrence of irregular firing in Sorcs2−/− mice. This was paralleled by abnormal acute behavioral responses to dopamine receptor agonists, suggesting fundamental differences in dopaminergic circuits and indicating a perturbation in the balance between the activities of the postsynaptic dopamine receptor DRD1 and the presynaptic inhibitory autoreceptor DRD2. Interestingly, the hyperactivity and drug response of Sorcs2−/− mice were markedly affected by novelty. Taken together, our findings show how loss of a candidate ADHD-risk gene has marked effects on dopaminergic circuit function and the behavioral response to the environment.

The effects of dissolved organic carbon on the reflex ventilatory responses of the neotropical teleost (Colossoma macropomum) to hypoxia or hypercapnia

Chemosphere ◽  
2021 ◽  
Vol 277 ◽  
pp. 130314
Author(s):  
Steve F. Perry ◽  
Kathleen M. Gilmour ◽  
Rafael M. Duarte ◽  
Chris M. Wood ◽  
Vera M.F. Almeida-Val ◽  
...  
Keyword(s):  
Organic Carbon ◽  
Dissolved Organic Carbon ◽  
Colossoma Macropomum ◽  
Ventilatory Responses

Computer simulation of experiments in responses to intravenous and inhaled CO2

1981 ◽  
Vol 50 (4) ◽  
pp. 835-843 ◽  
Author(s):  
W. S. Yamamoto
Keyword(s):  
Venous Return ◽  
Neural Signal ◽  
Set Point ◽  
Ventilatory Responses ◽  
Operating Level ◽  
Excitatory State ◽  
Co2 Level ◽  
Neural Excitation ◽  
Low Levels ◽  
Hypercapnic Response

A simulation of ventilatory responses to infused and inhaled CO2 at controlled cardiac output and high and low levels of neural excitation mimics comparable experiments in animals. The model suggests that at low levels of endogenous and exogenous CO2 load the alert quiescent animal will show hyperpnea to both test states associated with hypercapnia. The nonalert quiescent animal simulated will show an isocapnic response to endogenous load and hypercapnic response to exogenous load. The explanation of this behavior lies in the model formulation, which allows the neural signal from metabolically active sources to drive the proportional component of the controller below an operating level established by its set point. By this reasoning the excited but metabolically inactive animal should be paradoxically less sensitive to small changes in CO2, whether exogenous or endogenous, than the quiescent animal. The model demonstrates further that a neural "exercise" signal in proportion to venous return better simulates observations in which CO2 load and venous return are dissociated than one in which the neural signal is computed from metabolism. The use of delta V/delta P slopes as estimates of sensitivity go awry in experiment and simulation when blood flow, CO2 level, and neural excitatory state are dissociated. This is particularly true when the organism is operating at and below the hypothesized set point.

Hypoxic and hypercapnic ventilatory responses in rats with polycystic ovaries

2015 ◽  
Vol 217 ◽  
pp. 17-24 ◽  
Author(s):  
Luis Henrique Montrezor ◽  
Débora de Carvalho ◽  
Mirela B. Dias ◽  
Janete A. Anselmo-Franci ◽  
Kênia C. Bícego ◽  
...  
Keyword(s):  
Polycystic Ovaries ◽  
Ventilatory Responses

Sexual influence on the control of breathing

1983 ◽  
Vol 54 (4) ◽  
pp. 874-879 ◽  
Author(s):  
D. P. White ◽  
N. J. Douglas ◽  
C. K. Pickett ◽  
J. V. Weil ◽  
C. W. Zwillich
Keyword(s):  
Ventilatory Response ◽  
Minute Ventilation ◽  
Premenopausal Women ◽  
Co2 Production ◽  
Menstrual Phase ◽  
Co2 Partial Pressure ◽  
Ventilatory Responses ◽  
Chemical Stimuli ◽  
Low Levels ◽  
Normal Women

Previous investigation has demonstrated that progesterone, a hormone found in premenopausal women, is a ventilatory stimulant. However, fragmentary data suggest that normal women may have lower ventilatory responses to chemical stimuli than men, in whom progesterone is found at low levels. As male-female differences have not been carefully studied, we undertook a systematic comparison of resting ventilation and ventilatory responses to chemical stimuli in men and women. Resting ventilation was found to correlate closely with CO2 production in all subjects (r = 0.71, P less than 0.001), but women tended to have a greater minute ventilation per milliliter of CO2 produced (P less than 0.05) and consequently a lower CO2 partial pressure (PCO2) (men 35.1 +/- 0.5 Torr, women 33.2 +/- 0.5 Torr; P less than 0.02). Women were also found to have lower tidal volumes, even when corrected from body surface area (BSA), and greater respiratory frequency than comparable males. The hypoxic ventilatory response (HVR) quantitated by the shape parameter A was significantly greater in men [167 +/- 22 (SE)] than in women (109 +/- 13; P less than 0.05). In men this hypoxic response was found to correlate closely with O2 consumption (r = 0.75, P less than 0.001) but with no measure of size or metabolic rate in women. The hypercapnic ventilatory response, expressed as the slope of ventilation vs. PCO2, was also greater in men (2.30 +/- 0.23) than in women (1.58 +/- 0.19, P less than 0.05). Finally women tended to have higher ventilatory responses in the luteal than in the follicular menstrual phase, but this was significant only for HVR (P less than 0.05). Women, with relatively higher resting ventilation, have lower responses to hypoxia and hypercapnia.

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