Structure-Function of the Cytochrome b 6 f Lipoprotein Complex

Author(s):  
William A. Cramer ◽  
S. Saif Hasan
Author(s):  
William A. Cramer ◽  
Saif Hasan ◽  
Satarupa Bhaduri ◽  
Jillian Ness ◽  
Sujith Puthyaveetil ◽  
...  

Author(s):  
J. A. Clarke ◽  
D. N. Landon ◽  
P. R. Ward

Intra-mitochondrial crystals have been noted in muscle biopsies from patients in a wide variety of diseased states. As far as we are aware, none of these crystals have been subjected to detailed crystallographic analysis. Recently, similar crystals were observed in a biopsy from a patient with a mitochondrial myopathy, characterised by a deficiency in reducible cytochrome b (Morgan-Hughes, J. A., Darveniza, P., Kahn, S. N., Landon, D. N., Sherratt, R. M., Land, J. M. and Clark, J. B., 1977, Brain, In Press). Aldehyde-fixed, osmicated resin imbedded material was examined using Siemens, JEOL and Phillips electron microscopes with goniometer specimen stages. The crystals generally lay between the outer and inner mitochondrial membranes and measured 1 - 3 μm in length and 0.1 - 0.3 μm in width. Characteristically, these crystals revealed specific periodicities.


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