Therapeutic Strategies of Natural Agents on Triple-Negative Breast Cancer

2018 ◽  
pp. 321-341
Author(s):  
Ashok Kumar Pandurangan ◽  
Mohd Rais Mustafa
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Therapeutic Strategies ◽  
Natural Agents

scholarly journals Therapeutic Strategies in Triple-Negative Breast Cancer

Breast Care ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 6-7 ◽  
Author(s):  
Angelo Paradiso ◽  
Christian F. Singer
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Therapeutic Strategies

scholarly journals Diagnosis and Therapy of Triple-Negative Breast Cancer (TNBC) – Recommendations for Daily Routine Practice

2019 ◽  
Vol 79 (06) ◽  
pp. 605-617 ◽  
Author(s):  
Andreas Schneeweiss ◽  
Carsten Denkert ◽  
Peter A. Fasching ◽  
Carlo Fremd ◽  
Oleg Gluz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Therapeutic Strategies ◽  
Routine Practice ◽  
Daily Routine ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Tumour Biology ◽  
Therapeutic Concepts

AbstractThe rapid increase in knowledge in tumour biology and tumour pathogenesis of triple-negative breast cancer (TNBC) has resulted in new therapeutic approaches and new therapeutic concepts for treatment. For years, TNBC has been considered to be a difficult-to-treat tumour due to its generally aggressive tumour biology and in view of limited therapeutic options. The risk of recurrence and metastasis is higher than in the case of other breast cancer subtypes of the same stage. In addition to surgery and radiation in the curative situation, systemic chemotherapy with anthracyclines and/or taxanes is still the therapy of choice. New therapeutic approaches are based on the knowledge that TNBC is a molecularly very heterogeneous disease. Research groups are working to classify TNBC better and better on a molecular level and use this molecular subtyping as the basis for new therapeutic strategies. The most promising new approaches and considerations regarding the therapy of TNBCs are shown below. In addition, the current therapeutic strategies are discussed using a fictitious case history, taking the current data and the resultant therapeutic consequence into account.

scholarly journals Integrative analysis of metabolic subtypes in triple-negative breast cancer reveals new therapeutic strategies

2019 ◽  
Vol 30 ◽  
pp. ix2 ◽  
Author(s):  
Y. Gong ◽  
P. Ji ◽  
Y. Xiao ◽  
D. Ma ◽  
M.-L. Jin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Therapeutic Strategies ◽  
Integrative Analysis

Multifunctional nanodiamonds-based nanoplatform for enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via autophagy regulation strategy

Nanoscale ◽  
2021 ◽  
Author(s):  
Xinyue Cui ◽  
Zhaoyuan Liang ◽  
Jianqing Lu ◽  
Xuan Wang ◽  
Fan Jia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Combination Therapy ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Therapeutic Strategies ◽  
Biological Behavior ◽  
Therapeutic Resistance ◽  
Multiple Treatments ◽  
Mild Temperature

Due to the aggressive biological behavior, lacking of specific targets and unconquered therapeutic resistance of Triple Negative Breast Cancer (TNBC), current therapeutic strategies were still limited. Combining multiple treatments have...

Novel Therapeutic Strategies of Triple-Negative Breast Cancer

2020 ◽  
pp. 157-198
Author(s):  
Guifei Li ◽  
Hui Yao ◽  
Shichao Yan ◽  
Shujun Fu ◽  
Xiyun Deng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Therapeutic Strategies ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

scholarly journals Novel therapeutic strategies in the treatment of triple-negative breast cancer

2017 ◽  
Vol 9 (7) ◽  
pp. 493-511 ◽  
Author(s):  
Karima Oualla ◽  
Heba M. El-Zawahry ◽  
Banu Arun ◽  
James M. Reuben ◽  
Wendy A. Woodward ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Growth Factor Receptor ◽  
Therapeutic Strategies ◽  
Her2 Status ◽  
Biological Complexity ◽  
Epidermal Growth ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that is defined by negative estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status. Treating patients with TNBC remains clinically challenging, as patients are not candidates for endocrine or HER2-directed therapy. As a result, chemotherapy with traditional agents such as anthracyclines and taxanes remains the only available option with moderate success. Recent discoveries have revealed that TNBC is a heterogeneous disease at the clinical, histological and molecular levels. The use of biomarkers to identify distinct subsets of TNBC that derive the greatest benefit from presently approved as well as novel therapeutics has become the main focus of current research. The aim of this review is to explore the clinical and biological complexity of TNBC as well as identify novel therapeutic options that target the various molecular subsets of TNBC.

scholarly journals Long non-coding RNAs: implications in targeted diagnoses, prognosis, and improved therapeutic strategies in human non- and triple-negative breast cancer

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Rubén Rodríguez Bautista ◽  
Alette Ortega Gómez ◽  
Alfredo Hidalgo Miranda ◽  
Alejandro Zentella Dehesa ◽  
Cynthia Villarreal-Garza ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Therapeutic Strategies ◽  
Non Coding Rnas

scholarly journals PP2A as the Main Node of Therapeutic Strategies and Resistance Reversal in Triple-Negative Breast Cancer

Molecules ◽  
2017 ◽  
Vol 22 (12) ◽  
pp. 2277 ◽  
Author(s):  
Henan Zhao ◽  
Duojiao Li ◽  
Baojing Zhang ◽  
Yan Qi ◽  
Yunpeng Diao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Therapeutic Strategies ◽  
Resistance Reversal

scholarly journals Correction to: Long non-coding RNAs: implications in targeted diagnoses, prognosis, and improved therapeutic strategies in human non- and triple-negative breast cancer

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Rubén Rodríguez Bautista ◽  
Alette Ortega Gómez ◽  
Alfredo Hidalgo Miranda ◽  
Alejandro Zentella Dehesa ◽  
Cynthia Villarreal-Garza ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Therapeutic Strategies ◽  
Non Coding Rnas

Current Update on Natural Agents Against Triple Negative Breast Cancer

2020 ◽  
pp. 91-113
Author(s):  
Prathibha Sivaprakasam ◽  
Sureshkumar Anandasadagopan ◽  
Tamilselvi Alagumuthu ◽  
Ashok Kumar Pandurangan
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Poor Prognosis ◽  
Triple Negative ◽  
Notch Pathway ◽  
Chemotherapeutic Agents ◽  
Current Evidence ◽  
Research Needs ◽  
Disease Entity ◽  
Natural Agents

Breast cancer (BC) is sub-categorized into several well-recognized subtypes including estrogen receptor (ER), progesterone receptor (PR), and HER2 triple-negative breast cancer (TNBC). It is a heterogeneous disease entity constituting about 15% of breast cancer cases worldwide. TNBC is associated with poor prognosis and lack of sustained response to conventional chemotherapeutic agents. Although no approved targeted therapy is available for TNBCs, molecular-profiling efforts have revealed promising molecular targets such as the Wnt/β-catenin, STAT3, VEGF, EGFR, polyadenosine ribose polymerase inhibitors (PARPi) and DNA repair pathway, androgen pathway, and NOTCH pathway. Moreover, more research needs to be performed in the area of TNBC aiming at dissecting potential pathways and identifying potential molecular signatures to develop new targeted biologic modifiers. Natural agents are the abundant chemical compounds available from diverse plants. The authors aimed to summarize the current evidence and discuss the natural agents that target TNBC using different pathways.

Sign in / Sign up

Export Citation Format

Share Document