Functional Module Detection in Gene Regulatory Network Associated with Hepatocellular Carcinoma

2019 ◽  
pp. 137-150
Author(s):  
Sachin Bhatt ◽  
Kalpana Singh ◽  
Ravins Dohare
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Functional Module ◽  
Module Detection ◽  
Gene Regulatory

W1894 Elucidating Gene Regulatory Network of COOH-Terminal Truncated Hbx Associated With Hepatocellular Carcinoma

2010 ◽  
Vol 138 (5) ◽  
pp. S-761
Author(s):  
Alfred S. Cheng ◽  
Ranxu Zhu ◽  
Suki S. Lau ◽  
Wing Kit Yip ◽  
Yangchao Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Gene Regulatory

Differential network analysis depicts regulatory mechanisms for hepatocellular carcinoma from diverse backgrounds

2019 ◽  
Vol 15 (34) ◽  
pp. 3917-3934
Author(s):  
Min-Cheng Yu ◽  
Ji-Xiang Liu ◽  
Xiao-Lu Ma ◽  
Bo Hu ◽  
Pei-Yao Fu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Network Analysis ◽  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Regulatory Networks ◽  
Differential Network Analysis ◽  
Diverse Background ◽  
Differential Network ◽  
Diverse Backgrounds ◽  
Gene Regulatory

Aim: To elucidate the integrative combinational gene regulatory network landscape of hepatocellular carcinoma (HCC) molecular carcinogenesis from diverse background. Materials & methods: Modified gene regulatory network analysis was used to prioritize differentially regulated genes and links. Integrative comparisons using bioinformatics methods were applied to identify potential critical molecules and pathways in HCC with different backgrounds. Results: E2F1 with its surrounding regulatory links were identified to play different key roles in the HCC risk factor dysregulation mechanisms. Hsa-mir-19a was identified as showed different effects in the three HCC differential regulation networks, and showed vital regulatory role in HBV-related HCC. Conclusion: We describe in detail the regulatory networks involved in HCC with different backgrounds. E2F1 may serve as a universal target for HCC treatment.

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