Protein Structure, Dynamics and Assembly: Implications for Drug Discovery

2021 ◽  
pp. 91-122
Author(s):  
Arangasamy Yazhini ◽  
Sohini Chakraborti ◽  
Narayanaswamy Srinivasan
Keyword(s):  
Protein Structure ◽  
Drug Discovery ◽  
Structure Dynamics

scholarly journals Wrangling Shape-Shifting Morpheeins to Tackle Disease and Approach Drug Discovery

2020 ◽  
Vol 7 ◽  
Author(s):  
Eileen K. Jaffe
Keyword(s):  
Protein Structure ◽  
Drug Discovery ◽  
Inborn Error ◽  
Inborn Error Of Metabolism ◽  
Bioactive Molecules ◽  
Structure Dynamics ◽  
Functional Consequences

Homo-multimeric proteins that can come apart, change shape, and reassemble differently with functional consequences have been called morpheeins and/or transformers; these provide a largely unexplored context for understanding disease and developing allosteric therapeutics. This article describes such proteins within the context of protein structure dynamics, provides one detailed example related to an inborn error of metabolism and potential herbicide development, and describes the context for applying these ideas for understanding disease and designing bioactive molecules, such as therapeutics.

scholarly journals HDX-Analyzer: a novel package for statistical analysis of protein structure dynamics

2011 ◽  
Vol 12 (Suppl 1) ◽  
pp. S43 ◽  
Author(s):  
Sanmin Liu ◽  
Lantao Liu ◽  
Ugur Uzuner ◽  
Xin Zhou ◽  
Manxi Gu ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Protein Structure ◽  
Structure Dynamics
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