Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Liver Injury

Gypenoside is a saponins extract derived from the Gynostemma pentaphyllum. The purpose of this study was to evaluate the hepatoprotective and antifibrotic potential of Gypenoside on chronic liver injury induced by CCl 4 for 8 wks. The results indicated that the increase of SGOT, SGPT activities in CCl 4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio. For the study of anti-fibrotic potential, Gypenoside reduced the collagen content by 33%. These phenomena were confirmed by pathologic observation; thinner bands of liver collagen were found. The results suggest that Gypenoside has hepatoprotective and anti-fibrotic activities.

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Therapeutic effect of N-acetylcysteine on chemotherapy-induced liver injury

Irish Journal of Medical Science (1971 -) ◽

10.1007/s11845-020-02219-1 ◽

2020 ◽

Vol 189 (4) ◽

pp. 1189-1194 ◽

Cited By ~ 1

Author(s):

Nilgun Eroglu ◽

Erol Erduran ◽

Gokce Pinar Reis ◽

Aysenur Bahadır

Keyword(s):

Liver Injury ◽

Therapeutic Effect

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Saikokeishito Extract Exerts a Therapeutic Effect on α-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue

Journal of Clinical Biochemistry and Nutrition ◽

10.3164/jcbn.40.31 ◽

2007 ◽

Vol 40 (1) ◽

pp. 31-41 ◽

Cited By ~ 6

Author(s):

Yoshiji Ohta ◽

Mutsumi Kongo-Nishimura ◽

Takahiro Hayashi ◽

Akira Kitagawa ◽

Tatsuya Matsura ◽

...

Keyword(s):

Oxidative Stress ◽

Liver Injury ◽

Therapeutic Effect ◽

Liver Tissue ◽

Neutrophil Infiltration ◽

And Oxidative Stress

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SDF-1/CXCR4 Augments the Therapeutic Effect of Bone Marrow Mesenchymal Stem Cells in the Treatment of Lipopolysaccharide-Induced Liver Injury by Promoting Their Migration Through PI3K/Akt Signaling Pathway

Cell Transplantation ◽

10.1177/0963689720929992 ◽

2020 ◽

Vol 29 ◽

pp. 096368972092999 ◽

Cited By ~ 1

Author(s):

Guanghui Xiu ◽

Xiuling Li ◽

Yunyu Yin ◽

Jintao Li ◽

Bingqin Li ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Liver Injury ◽

Signaling Pathway ◽

Therapeutic Effect ◽

Acute Liver Injury ◽

Akt Signaling ◽

Akt Signaling Pathway

Mesenchymal stem cells (MSCs) are thought to have great potential in the therapy of acute liver injury. It is possible that these cells may be regulated by the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling axis, which has been shown to promote stem cells migration in the inflammation-associated diseases. However, the effects of SDF-1/CXCR4 axis on the MSCs-transplantation-based treatment for acute liver injury and the underlying mechanisms are largely unknown. In this study, we sought to determine whether SDF-1/CXCR4 would augment the therapeutic effect of bone marrow mesenchymal stem cells (BMSCs) by promoting their migration, which may result from activating the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, in a rat acute liver injury model induced by lipopolysaccharide (LPS). We found that BMSCs transplantation markedly attenuated liver injury and improved the survival of LPS-treated rats. Of interest, overexpression of CXCR4 in BMSCs could substantially promote their migration both in vitro and in vivo, and result in even better therapeutic effects. This might be attributed to the activation of PI3K/Akt signaling pathway in BMSCs that is downstream of CXCR4, as demonstrated by the use of the CXCR4 antagonist AMD3100 and PI3K pathway inhibitor LY294002 assays in vitro and in vivo. Together, our results unraveled a novel molecular mechanism for the therapeutic effect of BMSCs for the treatment of acute liver injury, which may shed a new light on the clinical application of BMSCs for acute liver failure.

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