Relations between ?-adrenoceptor occupancy and increases of contractile force and adenylate cyclase activity induced by catecholamines in human ventricular myocardium

2004 ◽  
Vol 339-339 (1-2) ◽  
pp. 99-112 ◽  
Author(s):  
Alberto J. Kaumann ◽  
Horst Lemoine ◽  
Ulrich Schwederski-Menke ◽  
Bernhard Ehle
Keyword(s):  
Adenylate Cyclase ◽  
Ventricular Myocardium ◽  
Contractile Force ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Human Ventricular Myocardium

Age-dependent mechanical and biochemical responses to glucagon

1976 ◽  
Vol 230 (6) ◽  
pp. 1590-1593 ◽  
Author(s):  
G Ahumada ◽  
BE Sobel ◽  
WF Friedman
Keyword(s):  
Adenylate Cyclase ◽  
Ventricular Myocardium ◽  
Fetal Tissue ◽  
Particulate Fraction ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Glucagon Receptor ◽  
Tension Development ◽  
Receptor Sites ◽  
Age Dependent

The age-dependent relationships between glucagon-induced alterations in myocardial mechanics and adenylate cyclase activity in fetal and newborn lambs and adult sheep were evaluated. Glucagon substantially augmented the force of contraction of ventricular myocardium isolated from the adult but not from the fetus or newborn. Similarly, substantial increases in the spontaneous frequency of contraction and tension were observed in adult atrial strips, but not in the fetus or newborn. Comparable activities of phosphodiesterase were observed in extracts from fetal and adult myocardium and were unaltered by the addition of glucagon. Adenylate cyclase activity in adult myocardial homogenate and particulate fractions was comparable to that of fetal tissue. Glucagon stimulation of the particulate fraction produced no change in fetal adenylate cyclase activity whereas a 43% increase in activity was observed in preparations from adult tissue. Sodium fluoride and epinephrine augmented adenylate cyclase activity in both fetal and adult myocardium. Thus, glucagon produced age-dependent, parallel changes in heart rate, active tension development, and particulate fraction adenylate cyclase activity, suggesting that these chronotropic and inotropic responses are indeed mediated by adenylate cyclase and that lack of response in the fetus reflects the absence of mature glucagon receptor sites.

scholarly journals Breed-related differences in age-dependent down-regulation of the β1-adrenoceptor and adenylate cyclase activity in atrial and ventricular myocardium of Cröllwitzer (“wild-type”) turkeys

2018 ◽  
Vol 97 (3) ◽  
pp. 1041-1049
Author(s):  
Sandra Hoffmann ◽  
Julia Böhme ◽  
Christian Kube ◽  
Michael Pees ◽  
Jörg Haufe ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Ventricular Myocardium ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Wild Type ◽  
Down Regulation ◽  
Age Dependent

scholarly journals Effects of NKH477, a novel water-soluble forskolin derivative, on contractile force and adenylate cyclase activity in isolated guinea-pig ventricular muscles

1990 ◽  
Vol 52 ◽  
pp. 281
Author(s):  
Ryo Fujihara ◽  
Akira Fujita ◽  
Keiko Sone ◽  
Etsuko Karibe ◽  
Mitsue Noguchi ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Guinea Pig ◽  
Contractile Force ◽  
Water Soluble ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity

Cytochemical Evidence for Presynatic β-Adrenergic Regulation of Secretion in the Developing Rat Submandibular Gland

1977 ◽  
Vol 35 ◽  
pp. 430-431
Author(s):  
L.S. Cutler
Keyword(s):  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Submandibular Gland ◽  
Neonatal Rat ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Parotid Glands ◽  
Adrenergic Agonist ◽  
Rat Submandibular Gland

Many studies previously have shown that the B-adrenergic agonist isoproterenol and the a-adrenergic agonist norepinephrine will stimulate secretion by the adult rat submandibular (SMG) and parotid glands. Recent data from several laboratories indicates that adrenergic agonists bind to specific receptors on the secretory cell surface and stimulate membrane associated adenylate cyclase activity which generates cyclic AMP. The production of cyclic AMP apparently initiates a cascade of events which culminates in exocytosis. During recent studies in our laboratory it was observed that the adenylate cyclase activity in plasma membrane fractions derived from the prenatal and early neonatal rat submandibular gland was retractile to stimulation by isoproterenol but was stimulated by norepinephrine. In addition, in vitro secretion studies indicated that these prenatal and neonatal glands would not secrete peroxidase in response to isoproterenol but would secrete in response to norepinephrine. In contrast to these in vitro observations, it has been shown that the injection of isoproterenol into the living newborn rat results in secretion of peroxidase by the SMG (1).

Platelet adenylate cyclase activity in israeli victims of iraqi Scud missile attacks with post-traumatic stress disorder

1994 ◽  
Vol 114 (3) ◽  
pp. 509-512 ◽  
Author(s):  
Ronit Weizmann ◽  
Eitan Gur ◽  
Nathaniel Laor ◽  
Ahuva Reiss ◽  
Uri Muller ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Post Traumatic Stress ◽  
Post Traumatic
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