Effects of AN-132, a novel antiarrhythmic lidocaine analogue, and of lidocaine on membrane ionic currents of guinea-pig ventricular myocytes

2004 ◽  
Vol 339-339 (1-2) ◽  
pp. 221-229 ◽  
Author(s):  
K. Ono ◽  
T. Kiyosue ◽  
M. Arita
Keyword(s):  
Guinea Pig ◽  
Ventricular Myocytes ◽  
Ionic Currents ◽  
Membrane Ionic Currents

Effects of halothane on membrane ionic currents in guinea pig atrial and ventricular myocytes

1989 ◽  
Vol 33 (3) ◽  
pp. 239-244 ◽  
Author(s):  
K. HIROTA ◽  
Y. ITO ◽  
A. MASUDA ◽  
Y. MOMOSE
Keyword(s):  
Guinea Pig ◽  
Ventricular Myocytes ◽  
Ionic Currents ◽  
Membrane Ionic Currents

scholarly journals Effects of BDF 9198 on action potentials and ionic currents from guinea-pig isolated ventricular myocytes

2000 ◽  
Vol 130 (8) ◽  
pp. 1753-1766 ◽  
Author(s):  
K H Yuill ◽  
M K Convery ◽  
P C Dooley ◽  
S A Doggrell ◽  
J C Hancox
Keyword(s):  
Guinea Pig ◽  
Action Potentials ◽  
Ventricular Myocytes ◽  
Ionic Currents ◽  
Isolated Ventricular Myocytes

Palmitoyl-L-carnitine acts like ouabain on voltage, current, and contraction in guinea pig ventricular cells

1995 ◽  
Vol 268 (3) ◽  
pp. H1027-H1036 ◽  
Author(s):  
J. B. Shen ◽  
A. J. Pappano
Keyword(s):  
Guinea Pig ◽  
Ventricular Myocytes ◽  
Present Report ◽  
Ionic Currents ◽  
Pump Current ◽  
Membrane Potentials ◽  
Cell Shortening ◽  
Ventricular Cells ◽  
Ramp Voltage ◽  
Inward Currents

We previously showed that palmitoyl-L-carnitine (L-PC) inhibits the Na/K pump current (INa/K). In the present report, we test the hypothesis that L-PC, like ouabain, should increase myocyte shortening. Membrane potentials or ionic currents were recorded simultaneously with cell shortening in single guinea pig ventricular myocytes at room temperature (22 degrees C). Like ouabain, L-PC (1 microM) reversibly depolarized the resting membrane, decreased action potential duration, and increased the amplitude of myocyte contractions. Neither L-PC nor ouabain had a significant effect on Ca current (ICa). When L-PC increased cell shortening during ramp voltage clamp, membrane current shifted inward at voltages negative to -20 mV and shifted outward at more positive voltages. Similar to toxic concentrations of ouabain, L-PC induced transient inward currents and aftercontractions. At concentrations that inhibit INa/K, L-PC acted like ouabain to produce characteristic effects on membrane potentials, currents, and cell contractions that were unrelated to significant changes in ICa. L-PC reduces surface negative charge of erythrocytes and myocytes (C. Gruver and A. J. Pappano, J. Mol. Cell. Cardiol. 25: 1275–1284, 1993), and we speculate that L-PC inhibits INa/K by this mechanism.

Effects of ruthenium red on membrane ionic currents in urinary bladder smooth muscle cells of the guinea-pig

1998 ◽  
Vol 435 (5) ◽  
pp. 645-653 ◽  
Author(s):  
Masaru Hirano ◽  
Y. Imaizumi ◽  
Katsuhiko Muraki ◽  
A. Yamada ◽  
Minoru Watanabe
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Ionic Currents ◽  
Ruthenium Red ◽  
Bladder Smooth Muscle ◽  
Urinary Bladder Smooth Muscle ◽  
Membrane Ionic Currents

scholarly journals Effects of 9-methyl-7-bromoeudistomin D, a novel Ca2+ releaser, on [Ca2+]i and membrane ionic currents in single smooth muscle cells isolated from urinary bladder of the guinea-pig.

1996 ◽  
Vol 71 ◽  
pp. 211
Author(s):  
Kaoru Atsuki ◽  
Yuichi Torii ◽  
Satoshi Henmi ◽  
Yuji Imaizumi ◽  
Yasushi Ohizumi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Ionic Currents ◽  
Membrane Ionic Currents

scholarly journals Effects of Astragaloside IV on Action Potentials and Ionic Currents in Guinea-Pig Ventricular Myocytes

2013 ◽  
Vol 36 (4) ◽  
pp. 515-521 ◽  
Author(s):  
Meimi Zhao ◽  
Jinsheng Zhao ◽  
Guilin He ◽  
Xuefei Sun ◽  
Xueshi Huang ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Action Potentials ◽  
Ventricular Myocytes ◽  
Ionic Currents ◽  
Astragaloside Iv

scholarly journals Effects of wortmannin on membrane ionic currents and contraction in single smooth muscle cells isolated from guinea-pig duodenum

1995 ◽  
Vol 67 ◽  
pp. 205
Author(s):  
Kaoni Atsuki ◽  
Katsuhiko Muraki ◽  
Yuji Imaizumi ◽  
Minoru Watanabe
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Ionic Currents ◽  
Membrane Ionic Currents
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