Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rat, 5-HT1D in the rabbit and guinea-pig brain cortex

1991 ◽  
Vol 343 (4) ◽  
pp. 353-364 ◽  
Author(s):  
N. Limberger ◽  
R. Deicher ◽  
K. Starke
Keyword(s):  
Guinea Pig ◽  
Brain Cortex ◽  
Species Differences ◽  
Pig Brain ◽  
Serotonin Autoreceptors ◽  
Guinea Pig Brain

SOME PHYSICAL, CHEMICAL AND BIOCHEMICAL PROPERTIES OF RIBOSOMAL RNA FROM GUINEA PIG BRAIN CORTEX

1965 ◽  
Vol 12 (7) ◽  
pp. 607-611 ◽  
Author(s):  
Sakae Yamagami ◽  
Yukio Kawakita ◽  
Syuzo Naka
Keyword(s):  
Guinea Pig ◽  
Ribosomal Rna ◽  
Brain Cortex ◽  
Biochemical Properties ◽  
Physical Chemical ◽  
Pig Brain ◽  
Guinea Pig Brain

Effects of Oxygen at High Pressure on the Transport of Potassium, Sodium and Glutamate in Guinea Pig Brain Cortex

1957 ◽  
Vol 190 (1) ◽  
pp. 157-162 ◽  
Author(s):  
S. A. Kaplan ◽  
S. N. Stein
Keyword(s):  
Central Nervous System ◽  
High Pressure ◽  
Guinea Pig ◽  
Brain Cortex ◽  
High Pressures ◽  
Inorganic Ions ◽  
Brain Cells ◽  
Pig Brain ◽  
The Central Nervous System ◽  
Guinea Pig Brain

Slices of guinea pig brain cortex were suspended in a medium containing inorganic ions (in concentrations similar to those present in plasma), glucose and glutamate. They were shaken for 90 minutes at 37°C in oxygen, the partial pressure of which was varied from 1 to 11 atm. absolute. Raising the pressure above 4 atm. absolute resulted in the slices losing considerable quantities of potassium. At 6 atm. absolute the slices accumulated considerably less glutamic acid than they did at 1 atm. These findings suggest that brain cells are unable to maintain their normal concentrations of these two substances when exposed to oxygen at high pressure and suggest a possible mechanism for the origin of the disturbances of function in the central nervous system of animals exposed to high pressures of oxygen.

Potassium accumulation in guinea pig brain cortex slices

1960 ◽  
Vol 5 (2) ◽  
pp. 199-201 ◽  
Author(s):  
G. Gárdos
Keyword(s):  
Guinea Pig ◽  
Brain Cortex ◽  
Potassium Accumulation ◽  
Pig Brain ◽  
Brain Cortex Slices ◽  
Cortex Slices ◽  
Guinea Pig Brain

THE INCORPORATION OF [14C]GLYCINE INTO THE PROTEIN OF GUINEA PIG BRAIN CORTEX SLICES

1962 ◽  
Vol 9 (3) ◽  
pp. 281-288 ◽  
Author(s):  
K. Mase ◽  
Y. Takahashi ◽  
K. Ogata
Keyword(s):  
Guinea Pig ◽  
Brain Cortex ◽  
Pig Brain ◽  
Brain Cortex Slices ◽  
Cortex Slices ◽  
Guinea Pig Brain

TRANSPORT OF MONOSACCHARIDES INTO SLICES OF GUINEA-PIG BRAIN CORTEX

1969 ◽  
pp. 110 ◽  
Author(s):  
P. Joanny ◽  
J. Corriol ◽  
A. Kleinzeller ◽  
H.H. Hillman
Keyword(s):  
Guinea Pig ◽  
Brain Cortex ◽  
Pig Brain ◽  
Guinea Pig Brain

Evidence for presynaptic location of inhibitory 5-HT1D\-like autoreceptors in the guinea-pig brain cortex

1996 ◽  
Vol 353 (3) ◽  
pp. 281-289 ◽  
Author(s):  
M. B�hlen ◽  
K. Fink ◽  
C. B�ing ◽  
M. G�thert
Keyword(s):  
Guinea Pig ◽  
Brain Cortex ◽  
Pig Brain ◽  
Guinea Pig Brain

scholarly journals Li+ increases accumulation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in cholinergically stimulated brain cortex slices in guinea pig, mouse and rat. The increases require inositol supplementation in mouse and rat but not in guinea pig

1992 ◽  
Vol 282 (2) ◽  
pp. 377-385 ◽  
Author(s):  
C H Lee ◽  
J F Dixon ◽  
M Reichman ◽  
C Moummi ◽  
G Los ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Depressive Disorders ◽  
Brain Cortex ◽  
Mass Measurement ◽  
Plasma Concentrations ◽  
Therapeutic Implications ◽  
Pig Brain ◽  
Brain Cortex Slices ◽  
Cortex Slices ◽  
Guinea Pig Brain

Li+, beginning at a concentration as low as 1 mM, produced a time- and dose-dependent increase in accumulation of [3H]Ins(1,4,5)P3 and [3H]Ins(1,3,4,5)P4 in acetylcholine (ACh)-stimulated guinea-pig brain cortex slices prelabelled with [3H]inositol and containing 1 mM-inositol in the final incubation period. Similar results were obtained by mass measurement of samples incubated with 10 mM-Li+ by using a receptor-binding assay, although the percentage stimulation of Ins(1,4,5)P3 accumulation by Li+ was somewhat less by this assay. The increase in accumulation of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 by Li+ was absolutely dependent on the presence of ACh. In the absence of added inositol, 1-5 mM-Li+ produced smaller increases in Ins(1,4,5)P3, but the Li(+)-dependent increase in Ins(1,3,4,5)P4 was not as affected by inositol omission. In previous studies with cholinergically stimulated rat and mouse brain cortex slices, Li+ inhibited accumulation of Ins(1,4,5)P3 in rat and inhibited Ins(1,3,4,5)P4 accumulation in rat and mouse [Batty & Nahorski (1987) Biochem. J. 247, 797-800; Whitworth & Kendall (1988) J. Neurochem. 51, 258-265]. We found that Li+ inhibited both Ins(1,4,5)P3 and Ins(1,3,4,5)P4 accumulation in these species, but we could reverse this inhibition by adding 10-30 mM-inositol; we then observed a Li(+)-induced increase in Ins(1,4,5)P3 and Ins(1,3,4,5)P4. The species differences observed in the absence of supplemented inositol were explained by the fact that a much higher concentration of inositol was required to bring the Li(+)-elevated levels of CDP-diacylglycerol (CDPDG) down to baseline in the rat and mouse. These data suggest that inositol is more rate-limiting for phosphatidylinositol synthesis in the presence of Li+ in rat and mouse, which can account for the previous reports of inhibition of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 accumulation by this ion in these species. Thus, in all species examined. Li+ could be shown to increase accumulation of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 in cholinergically stimulated brain cortex slices if the slices were supplemented with sufficient inositol to bring the Li(+)-elevated level of CDPDG down to near baseline, as seen in the absence of Li+. In guinea-pig brain cortex slices, increases in Ins(1,4,5)P3 and Ins(1,3,4,5)P4 accumulation could then be seen at Li+ concentrations as low as 1 mM, which falls within the therapeutic range of plasma concentrations in the treatment of manic-depressive disorders. These observations may have therapeutic implications.

scholarly journals Functional characterization of the 5-HT terminal autoreceptor in the guinea-pig brain cortex

1996 ◽  
Vol 117 (2) ◽  
pp. 384-388 ◽  
Author(s):  
Claire Roberts ◽  
Jeannette Watson ◽  
Melanie Burton ◽  
Gary W. Price ◽  
Brian J. Jones
Keyword(s):  
Guinea Pig ◽  
Brain Cortex ◽  
Functional Characterization ◽  
Pig Brain ◽  
Guinea Pig Brain

Presynaptic 5-HT autoreceptors modulate N-methyl-d-aspartate-evoked 5-hydroxytryptamine release in the guinea-pig brain cortex

1996 ◽  
Vol 300 (1-2) ◽  
pp. 79-82 ◽  
Author(s):  
Klaus Fink ◽  
Carsten Böing ◽  
Manfred Göthert
Keyword(s):  
Guinea Pig ◽  
Brain Cortex ◽  
Pig Brain ◽  
Guinea Pig Brain
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