Hepatocellular carcinoma with tumor thrombus in the inferior vena cava and right atrium

1994 ◽  
Vol 19 (4) ◽  
pp. 313-316 ◽  
Author(s):  
M. Kanematsu ◽  
T. Imaeda ◽  
H. Minowa ◽  
Y. Yamawaki ◽  
R. Mochizuki ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Inferior Vena Cava ◽  
Right Atrium ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Vena Cava

scholarly journals Transarterial Radioembolization Treatment of Advanced Hepatocellular Carcinoma Invading the Right Atrium

2021 ◽  
pp. 1-4
Author(s):  
Kabalane Yammine ◽  
◽  
Sarah Khalife ◽  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Inferior Vena Cava ◽  
Right Atrium ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Vena Cava ◽  
Treatment Strategies ◽  
Complete Response ◽  
Advanced Hepatocellular Carcinoma ◽  
The Right

Tumor thrombus infiltration of hepatocellular carcinoma (HCC) into the inferior vena cava and right atrium is rare and is associated with a poor prognosis due to the critical location of the tumor and the limited efficiency of the available treatment strategies. In this study, we report the case of a patient with advanced HCC and tumor thrombus in the inferior vena cava and right atrium who demonstrated complete response with mass retraction upon Yttrium-90 trans-arterial radioembolization (90Y- TARE) therapy. Throughout the 16 months follow-ups after the radioembolization, the patient was free of any complications, revealing no occurrence of radiation-induced pneumonitis or tumor recurrence.

scholarly journals Hepatocellular Carcinoma Presenting With Inferior Vena Cava Tumor Thrombus Extending to the Right Atrium: A Case Report

Cureus ◽  
2020 ◽  
Author(s):  
Ragia Aly ◽  
Sachin Gupta ◽  
Ruby Gupta ◽  
Vinicius M Jorge ◽  
Ahmed Ebraheem
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Inferior Vena Cava ◽  
Right Atrium ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Vena Cava ◽  
The Right

scholarly journals P883 Hepatocellular carcinoma presenting as a tumor thrombus extending from the inferior vena cava to the right atrium in echocardiography

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Beringuilho ◽  
A Baptista ◽  
J Baltazar ◽  
D Faria ◽  
P Magno ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Inferior Vena Cava ◽  
Right Atrium ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Vena Cava ◽  
Right Heart Failure ◽  
Portal System ◽  
Tumor Extension ◽  
The Right

Abstract Case A 74 year-old white male with COPD, type 2 Diabetes, Atrial Fibrillation and a Pacemaker presented to our hospital for a routine echocardiography follow-up for mild to moderate Aortic Stenosis. His past social history was positive for moderate alcohol consumption but negative for tattoos, recent travel, illicit drug use, blood transfusion or chemical exposure. During evaluation in the echocardiography lab the patient had symptoms of dyspnea, fatigue and abdominal distension. He was hemodynamically stable and physical examination was positive for signs os ascites and inferior limb oedema, but disclosed no scleral icterus, asterixis, spider angiomata or overt hepatomegaly. There was a recent weight gain of 10kg. Cardiac and pulmonary auscultation was unrevealing. The echocardiogram revealed moderate left ventricle dysfunction (EF ∼40%), moderate aortic stenosis and a dilated inferior vena cava (31mm) with an image of a mobile mass in the confluence of the central hepatic vein with the inferior vena cava with extension to the right atrium. Initial blood chemistry and blood count revealed macrocytic anaemia; slight increased y-GT, C-reactive protein and NT-proBNP (6210pg/mL). The patient was admitted and anticoagulation with subcutaneous enoxaparin was initiated with echocardiographic follow-up. An abdominal ultrasound was performed which a hyperecogenic mass (71x47mm) adjacent to the right and left supra-hepatic veins, highly suggestive of hepatocelullar carcinoma. A triple-phase abdominal CT confirmed a nodular lesion 70x50mm on segment VIII, compatible with hepatocellular carcinoma (Fig.1). A cardiac magnetic resonance was performed documenting the tumor extension to the inferior vena cava and right atrium, suggestive of tumor thrombus (Fig.2). Multidisciplinary meeting enrolled the patient in palliative care. The right heart failure picture was refractory to medical treatment and the patient progressed to multi organ failure and a consumptive state. He died approximately 20 days after diagnosis. Discussion Intravascular tumor extension, also known as Tumor thrombus (TT) is a rare complication of some forms of cancer. In the late stages of Hepatocellular carcinoma (HCC) a TT can form in the portal or hepatic vein. These are usually detected during tumor workup or during evaluation of cardiorespiratory symptoms in a patient with a known abdominal carcinoma. Tumor invasion to the portal system is quite common while invasion to the inferior vena cava (IVC) and/or heart without invasion of the portal system is rare. Tumor extension to the RA or IVC, most patients were either symptomatic, had cirrhosis, or both. Our patient presented mainly with signs of right heart failure refractory to medical treatment and had no signs of portal invasion or hypertension in the various image modalities. The prognosis for a HCC with extension to the IVC or RA is grim, with a 1 to 4 months of mean survival regardless of treatment choice. Abstract P883 Figure.

scholarly journals Liver resection for hepatocellular carcinoma with tumor thrombus in the inferior vena cava and right atrium

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S412
Author(s):  
S. Mori ◽  
T. Aoki ◽  
T. Shimizu ◽  
K. Tani ◽  
K.H. Park ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Inferior Vena Cava ◽  
Right Atrium ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Vena Cava

scholarly journals Sintilimab plus sorafenib: a novel regimen for hepatocellular carcinoma

Immunotherapy ◽  
2021 ◽  
Author(s):  
Xuhong Liu ◽  
Yong Yi
Keyword(s):  
Hepatocellular Carcinoma ◽  
Inferior Vena Cava ◽  
Right Atrium ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Malignant Tumors ◽  
Lung Metastases ◽  
Antiangiogenic Therapy ◽  
Vena Cava ◽  
New Treatments

Hepatocellular carcinoma is one of the most common malignant tumors in China and is also a major cause of cancer deaths worldwide. Recent advances in immunotherapy have identified new treatments in which immunotherapy can be combined with antiangiogenic therapy. We report a case of hepatocellular carcinoma with a tumor thrombus at the inferior vena cava–right atrium junction and multiple lung metastases after a multiple-course treatment. Treatment with sintilimab in combination with sorafenib led to a partial remission and immune-related hepatitis.

scholarly journals Hepatocellular Carcinoma with Inferior Vena Cava and Right Atrium Tumor Thrombus

2021 ◽  
Vol 28 (2) ◽  
pp. 10
Author(s):  
Arun Kumar Gunasekaran ◽  
Amit Malviya ◽  
Tony Ete ◽  
Animesh Mishra ◽  
Bhupen Barman ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Inferior Vena Cava ◽  
Cardiac Failure ◽  
Right Atrium ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Vena Cava ◽  
Hepatic Veins ◽  
Rare Presentation ◽  
Advanced Hcc

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer and cancer related deaths worldwide. Metastasis of HCC into the cardiac cavity is mostly caused by direct tumor thrombus invasion through the major hepatic veins and of vena cava inferior with continuous extension into the right cardiac cavity. Right heart metastasis without invasion of inferior vena cava (IVC), which may be caused by haematogenous spread of cancer cells, is rarely reported. We report a case of HCC with IVC and right atrium (RA) thrombus in a patient who presented to us with decompensated cardiac failure. Strikingly, the patient was young and with negative serum HBsAg, and anti-HCV results. Our case highlights a rare presentation of meta­static intracardiac tumor thrombus involving the RA in advanced HCC without any symptoms of cardiac failure, and henceforth, the role of screening echocardiography for all patients with advanced HCC especially with vena caval involvement to rule out intracardiac thrombus.

scholarly journals S2477 Hepatocellular Carcinoma With Tumor Thrombus in the Inferior Vena Cava and Right Atrium

2020 ◽  
Vol 115 (1) ◽  
pp. S1309-S1310
Author(s):  
Neera Sinha ◽  
Arsh Gupta ◽  
Stephen Mularz ◽  
Michael Bernstein
Keyword(s):  
Hepatocellular Carcinoma ◽  
Inferior Vena Cava ◽  
Right Atrium ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Vena Cava

Stereotactic Body Radiotherapy Treatment of Child-Pugh C Hepatocellular Carcinoma with Inferior Vena Cava Tumor Thrombus

2020 ◽  
pp. 1-4
Author(s):  
Emma C. Fields ◽  
Mrudula Bandaru ◽  
Scott Matherly ◽  
Emma C. Fields
Keyword(s):  
Hepatocellular Carcinoma ◽  
Inferior Vena Cava ◽  
Right Atrium ◽  
Stereotactic Body Radiotherapy ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Rare Complication ◽  
Vena Cava ◽  
Response To Treatment ◽  
The Right

The presence of tumor thrombus extending into the inferior vena cava (IVC) is a rare complication of hepatocellular carcinoma (HCC), presenting in only 3.8% of patients, resulting in a median survival of 1.9 months. Even rarer and likely with worse outcomes is a tumor extending from the IVC into the right atrium and ventricle. Here we present the case of a 55-year-old male with advanced liver cirrhosis from nonalcoholic steatohepatitis (NASH) with a diagnosis of HCC and IVC tumor thrombus invading into the right atrium and ventricle. The patient was treated with stereotactic body radiotherapy (SBRT) to 30Gy in 5 fractions delivered over 5 days targeting the right atrium, right ventricle and the outflow tract. Initially, the patient had a radiographic and clinical response to treatment, with minimal acute toxicities. Unfortunately, due to declining liver function, the patient subsequently entered hospice care and died 4 months posttreatment. This case demonstrates the poor prognosis of this advanced presentation of disease but suggests that SBRT is a safe and reasonable treatment approach for the reduction of IVC and cardiac tumor thrombus in HCC.

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