In vitro binding affinities of 4-chloro-, 2-methyl-, 4-methyl-, and 4-ethylindoleacetic acid to auxin-binding protein 1 (ABP1) correlate with their growth-stimulating activities

1996 ◽  
Vol 15 (1) ◽  
pp. 1-3 ◽  
Author(s):  
U. Rescher ◽  
A. Walther ◽  
C. Schiebl ◽  
D. Klämbt
Keyword(s):  
Binding Protein ◽  
Binding Affinities ◽  
In Vitro Binding ◽  
Vitro Binding ◽  
Auxin Binding ◽  
Auxin Binding Protein

scholarly journals A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities

2014 ◽  
Vol 24 (9) ◽  
pp. 1463-1474 ◽  
Author(s):  
Johanna Michl ◽  
Christian Scharinger ◽  
Miriam Zauner ◽  
Siegfried Kasper ◽  
Michael Freissmuth ◽  
...  
Keyword(s):  
Side Effects ◽  
Binding Affinities ◽  
Multivariate Approach ◽  
In Vitro Binding ◽  
Vitro Binding

Interaction of auxin-binding protein 1 with maize coleoptile plasma membranes in vitro

Planta ◽  
1997 ◽  
Vol 201 (4) ◽  
pp. 470-476 ◽  
Author(s):  
Christine Schiebl ◽  
Antje Walther ◽  
Ursula Rescher ◽  
Dieter Klämbt
Keyword(s):  
Plasma Membranes ◽  
Binding Protein ◽  
Maize Coleoptile ◽  
Auxin Binding ◽  
Auxin Binding Protein

ChemInform Abstract: Synthesis and in vitro Binding Affinities of 1-Azabicyclic Compounds as Muscarinic Ligands.

ChemInform ◽  
2010 ◽  
Vol 33 (9) ◽  
pp. no-no
Author(s):  
Joo Hwan Cha ◽  
Yong Seo Cho ◽  
Ae Nim Pae ◽  
Hun Yeong Koh ◽  
Daeyoung Jeong ◽  
...  
Keyword(s):  
Binding Affinities ◽  
In Vitro Binding ◽  
Vitro Binding ◽  
Muscarinic Ligands ◽  
Azabicyclic Compounds

scholarly journals Dimers and multimers of monoclonal IgG1 exhibit higher in vitro binding affinities to Fcγ receptors

mAbs ◽  
2009 ◽  
Vol 1 (5) ◽  
pp. 491-504 ◽  
Author(s):  
Yin Luo ◽  
Zhaojiang Lu ◽  
Stephen W. Raso ◽  
Clifford Entrican ◽  
Bruce Tangarone
Keyword(s):  
Binding Affinities ◽  
Fcγ Receptors ◽  
In Vitro Binding ◽  
Vitro Binding

A soluble auxin-binding protein from cultured tobacco tissues stimulates RNA synthesis in vitro

Planta ◽  
1984 ◽  
Vol 160 (2) ◽  
pp. 102-108 ◽  
Author(s):  
P. C. G. van der Linde ◽  
H. Bouman ◽  
A. M. Mennes ◽  
K. R. Libbenga
Keyword(s):  
Rna Synthesis ◽  
Binding Protein ◽  
Auxin Binding ◽  
Auxin Binding Protein

Synthesis and In vitro binding affinities of 1-azabicyclic compounds as muscarinic ligands

2001 ◽  
Vol 11 (21) ◽  
pp. 2855-2857 ◽  
Author(s):  
Joo Hwan Cha ◽  
Yong Seo Cho ◽  
Ae Nim Pae ◽  
Hun Yeong Koh ◽  
Daeyoung Jeong ◽  
...  
Keyword(s):  
Binding Affinities ◽  
In Vitro Binding ◽  
Vitro Binding ◽  
Muscarinic Ligands ◽  
Azabicyclic Compounds

Discovery of New AKT1 Inhibitors by Combination of In silico Structure Based Virtual Screening Approaches and Biological Evaluations

2019 ◽  
Author(s):  
Filip Fratev ◽  
Denisse A. Gutierrez ◽  
Renato J. Aguilera ◽  
suman sirimulla
Keyword(s):  
Virtual Screening ◽  
Success Rate ◽  
Protein Interactions ◽  
In Silico ◽  
Biological Data ◽  
In Vitro Binding ◽  
Vitro Binding ◽  
Screening Protocol ◽  
Screening Approaches

AKT1 is emerging as a useful target for treating cancer. Herein, we discovered a new set of ligands that inhibit the AKT1, as shown by in vitro binding and cell line studies, using a newly designed virtual screening protocol that combines structure-based pharmacophore and docking screens. Taking together with the biological data, the combination of structure based pharamcophore and docking methods demonstrated reasonable success rate in identifying new inhibitors (60-70%) proving the success of aforementioned approach. A detail analysis of the ligand-protein interactions was performed explaining observed activities.<br>

Sign in / Sign up

Export Citation Format

Share Document