Residual neurons in the lateral geniculate nucleus of adult cats following chronic disconnection from the cortex

1983 ◽  
Vol 52 (3) ◽  
Author(s):  
M. Madar�sz ◽  
J. Somogyi ◽  
V.L. Silakov ◽  
J. H�mori
Keyword(s):  
Lateral Geniculate Nucleus ◽  
Lateral Geniculate ◽  
Adult Cats

NMDAR-1 staining in the lateral geniculate nucleus of normal and visually deprived cats

2000 ◽  
Vol 17 (2) ◽  
pp. 187-196 ◽  
Author(s):  
JOKUBAS ZIBURKUS ◽  
MARTHA E. BICKFORD ◽  
WILLIAM GUIDO
Keyword(s):  
Nmda Receptors ◽  
Lateral Geniculate Nucleus ◽  
Cell Labeling ◽  
Acid Decarboxylase ◽  
Thalamic Nuclei ◽  
Neurofilament Protein ◽  
Lateral Geniculate ◽  
Wide Range ◽  
Soma Size ◽  
Adult Cats

In normal adult cats, a monoclonal antibody directed toward the NR-1 subunit of the N-methyl-d-aspartate (NMDA) receptor (Pharmingen, clone 54.1) produced dense cellular and neuropil labeling throughout all layers of the lateral geniculate nucleus (LGN) and adjacent thalamic nuclei, including the thalamic reticular, perigeniculate, medial intralaminar, and ventral lateral geniculate nuclei. Cellular staining revealed well-defined somata, and in some cases proximal dendrites. NMDAR-1 cell labeling was also evident in the LGN of early postnatal kittens, suggesting that developing LGN cells possess this receptor subunit at or before eye opening. Within the A-layers of the adult LGN, staining encompassed a wide range of soma sizes. Soma size comparisons of NMDAR-1 stained cells with those stained with an antibody directed toward a nonphosphorylated neurofilament protein (SMI-32), which selectively stains Y-relay cells (Bickford et al., 1998), or an antibody to glutamic acid decarboxylase (GAD), which stains for GABAergic interneurons, suggested that NMDA receptors are utilized by relay cells and interneurons. NMDAR-1 staining was also observed in the LGN of cats with early monocular lid suture. Although labeling was apparent in both deprived and nondeprived A-layers of LGN, the distribution of soma sizes was significantly different. In the deprived A-layers of LGN, staining was limited to small- and medium-sized cells. Cells with relatively large soma were lacking. However, cell density measurements as well as soma size comparisons with cells stained for Nissl substance suggested these differences were due to deprivation-induced cell shrinkage and not to a loss of NMDAR-1 staining in Y-cells. Taken together, these results suggest that NMDA receptors are utilized by both relay cells and interneurons in LGN and that alterations in early visual experience do not necessarily affect the expression of NMDA receptors in the LGN.

Morphology of physiologically identified retinogeniculate X- and Y-axons in the cat

1987 ◽  
Vol 58 (1) ◽  
pp. 1-32 ◽  
Author(s):  
M. Sur ◽  
M. Esguerra ◽  
P. E. Garraghty ◽  
M. F. Kritzer ◽  
S. M. Sherman
Keyword(s):  
Horseradish Peroxidase ◽  
Lateral Geniculate Nucleus ◽  
Morphological Analysis ◽  
Optic Tract ◽  
Pial Surface ◽  
Lateral Geniculate ◽  
Physiological Properties ◽  
Terminal Arbor ◽  
Subsequent Application ◽  
Adult Cats

1.We studied the morphology of individual, physiologically identified retinogeniculate axons in normal adult cats. The axons were recorded in the lateral geniculate nucleus or in the subjacent optic tract, characterized as X or Y by physiological criteria, penetrated, and injected with horseradish peroxidase. With subsequent application of appropriate histochemistry, the enzyme provides a complete label of the terminal arbors and parent trunks for morphological analysis. We have recovered for such analysis 26 X- and 25 Y-axons; of these, 14 X- and 12 Y-axons were studied in detail. 2. Within the optic tract, the parent trunk of every X-axon is located closer to the lateral geniculate nucleus and thus further from the pial surface than that of every Y-axon. This probably reflects the earlier development of X- than of Y-axons. Furthermore, the parent axon trunks of the X-axons are noticeably thinner than are those of the Y-axons. Every retinogeniculate X- and Y-axon in our sample branches within the optic tract. One of these branches heads dorsally to innervate the lateral geniculate nucleus and one heads medially and rostrally toward the midbrain, although none of these labeled axons were traced to a terminal arbor beyond the lateral geniculate nucleus. For Y-axons, all branches are of comparable diameter, but for X-axons, the branch heading toward the lateral geniculate nucleus is always noticeably thicker than is the branch directed toward the midbrain. 3. Every retinogeniculate X- and Y-axon produces the greatest portion of its terminal arbor in lamina A (if from the contralateral retina) or A1 (if from the ipsilateral retina). These arbors typically extend across most of the lamina along a projection line. Not a single terminal bouton from any axon was found in the inappropriate lamina A or A1 (i.e., in lamina A for ipsilaterally projecting axons or in lamina A1 for contralaterally projecting ones). Occasionally, an X-axon also innervates the medial interlaminar nucleus, and even more rarely does an X-axon innervate the C-laminae. In contrast, nearly all Y-axons from the contralateral retina branch to innervate part of the C-laminae (probably lamina C), and most from either retina also innervate the medial interlaminar nucleus. Although these details imply considerable variation in the overall pattern of retinogeniculate innervation for both X- and Y-axons, we found no physiological properties to correlate with this variation.(ABSTRACT TRUNCATED AT 400 WORDS)

Selective cell loss in the lateral geniculate nucleus of adult cats following binocular lid suture

1977 ◽  
Vol 130 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Walter L. Salinger ◽  
Mark A. Schwartz ◽  
Philip R. Wilkerson
Keyword(s):  
Lateral Geniculate Nucleus ◽  
Cell Loss ◽  
Lateral Geniculate ◽  
Adult Cats

Free postsynaptic sites in the lateral geniculate nucleus of adult cats following chronic decortication

1982 ◽  
Vol 225 (2) ◽  
Author(s):  
J. Somogyi ◽  
J. H�mori ◽  
V.L. Silakov
Keyword(s):  
Lateral Geniculate Nucleus ◽  
Lateral Geniculate ◽  
Adult Cats
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