Fine specificity and T-cell receptor ?-chain gene rearrangements of five H-2Db-specific cytotoxic T-cell clones

1987 ◽  
Vol 25 (3) ◽  
pp. 171-178 ◽  
Author(s):  
Marco W. Schilham ◽  
Rosmarie Lang ◽  
Hans Acha-Orbea ◽  
Robbert Benner ◽  
Rolf Joho ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cytotoxic T Cell ◽  
Chain Gene ◽  
Gene Rearrangements ◽  
T Cell Clones ◽  
Fine Specificity ◽  
Cell Clones ◽  
Receptor Chain

Preferential expression of a defined T-cell receptor β-chain gene in hapten-specific cytotoxic T-cell clones

Nature ◽  
1986 ◽  
Vol 322 (6077) ◽  
pp. 376-378 ◽  
Author(s):  
Ute Hochgeschwender ◽  
Hans Ulrich Weltzien ◽  
Klaus Eichmann ◽  
R. Bruce Wallace ◽  
Jörg T. Epplen
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cytotoxic T Cell ◽  
Chain Gene ◽  
T Cell Clones ◽  
Preferential Expression ◽  
Cell Clones ◽  
Β Chain

scholarly journals T cell receptor variable gene usage in a specific cytotoxic T cell response. Primary structure of the antigen-MHC receptor of four hapten-specific cytotoxic T cell clones.

1987 ◽  
Vol 165 (3) ◽  
pp. 591-600 ◽  
Author(s):  
A Iwamoto ◽  
P S Ohashi ◽  
H Pircher ◽  
C L Walker ◽  
E E Michalopoulos ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Primary Structure ◽  
Cell Receptor ◽  
Class I ◽  
Cytotoxic T Cell ◽  
Gene Products ◽  
T Cell Clones ◽  
Cell Clones ◽  
Variable Gene

The primary structure of the alpha and beta chains of the T cell antigen receptor in four cytotoxic T cell clones specific for N-iodoacetyl-sulfonic-naphthyl-ethylene-diamine (AED)-haptenated target cells displaying a particular class I MHC molecule has been determined. Two of the T cell clones, 8/10-2 and 5/10-20K, recognize AED-modified targets in association with H-2Kb, while the other two clones 5/10-20D and C9 react with AED-modified cells in the context of H-2Db. Comparison of the nucleotide sequences of both the alpha and beta chain cDNAs and their deduced protein sequences indicates that a specific variable gene segment was not used to recognize the hapten and/or class I gene products. Furthermore, there does not appear to be any conserved amino acid residues used in the AED-specific response other than the framework amino acids. However, when the two clones 8/10-2 and 5/10-20D were compared, a striking similarity was seen in the J segments. These two clones that recognize AED in the context of different MHC epitopes used identical J alpha (J alpha 810) and J beta (J beta 2.6) gene segments. C9, specific for AED-Db, shared identical V beta (V beta 6) and J beta gene segments (J beta 1.1) as those of a cytotoxic T cell that recognizes allogeneic targets expressing Db. These data indicate that a simple rule governing the usage of the variable regions of either the alpha or beta T cell receptor (TcR) genes in the recognition of antigen and MHC gene products cannot be formulated. However, subtle similarities can be detected in some situations between the primary structures of the TcR and the targets they recognize.

The Human T Cell Receptor: Analysis with Cytotoxic T Cell Clones

1983 ◽  
Vol 74 (1) ◽  
pp. 83-112 ◽  
Author(s):  
Ellis L. Reinherz ◽  
Stefan C. Meuer ◽  
Stuart F. Schlossman
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cytotoxic T Cell ◽  
T Cell Clones ◽  
Human T Cell ◽  
Cell Clones

Characterization of T-cell-receptor gamma (TRG) gene rearrangements in alloreactive T-cell clones

1989 ◽  
Vol 24 (2) ◽  
pp. 95-110 ◽  
Author(s):  
Jean Paul Moisan ◽  
Marc Bonneville ◽  
Isabelle Bouyge ◽  
Jean François Moreau ◽  
Jean Paul Soulillou ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Gene Rearrangements ◽  
T Cell Clones ◽  
Cell Clones ◽  
Alloreactive T Cell

Detection of Putative T cell Clones Using T cell Receptor β Chain Gene Clonality Assay in Korean Patients with Aplastic Anemia

2009 ◽  
Vol 29 (4) ◽  
pp. 269-276 ◽  
Author(s):  
Hyun-Jung Choi ◽  
Myung-Geun Shin ◽  
Hye-Ran Kim ◽  
Hyeoung-Joon Kim ◽  
Hoon Kook ◽  
...  
Keyword(s):  
T Cell ◽  
Aplastic Anemia ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
T Cell Clones ◽  
Korean Patients ◽  
Cell Clones ◽  
Β Chain
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